搜索结果: 1-15 共查到“知识库 基础医学 Research”相关记录17条 . 查询时间(0.195 秒)
Circulation Research | 周菁课题组与合作者发现基质刚度通过盘状结构域受体1（DDR1）的“液-液”相分离机制抑制Hippo通路（图）
高血压 糖尿病 高脂血症
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2023/8/11
动脉硬化在慢性肾病患者中普遍存在，其发生率和严重程度与心血管危险因素密切相关，包括年龄、高血压、糖尿病和高脂血症等。细胞外基质（ECM）刚度可影响血管平滑肌细胞（VSMCs）的表型和行为。ECM硬化会导致VSMC过度增殖、迁移，并从收缩表型向合成表型转化。然而，细胞是如何感知ECM刚度的改变，并将力学信号转化成生物学信号，这一问题仍有待深入研究。
Circulation Research | 孔炜课题组&孙金鹏课题组合作揭示细胞外基质蛋白Nidogen-2抑制血管钙化的新机制（图）
北京大学基础医学院 血管钙化 心血管杂志
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2023/8/11
2022年11年10日，北京大学基础医学院生理学与病理生理学系孔炜教授与孙金鹏教授合作在国际知名心血管杂志《Circulation Research》上在线发表了题为“Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification”的研究论文，揭示了细胞外基质蛋白Nidogen-2作为LGR4的一种新...
相分离（phase separation）指溶液中生物大分子（蛋白，DNA以及RNA等）在适当的温度、pH及盐浓度下，达到一定浓度后形成浓相和稀相（或者多相）的过程。近年的研究表明相分离是驱动细胞内无膜细胞器形成的重要机制之一，并且参与调控基因转录、信号传导、染色质组装和蛋白质降解等重要生物学过程。蛋白质是细胞内相分离液滴的主要组分之一，近几年来越来越多的蛋白被证明可发生相分离，其相分离过程的属性...
2021年11月18日，浙江大学生命科学研究院沈立课题组在Nucleic Acids Research杂志上在线发表了题为“Relaxed 3D genome conformation facilitates the pluripotent to totipotent-like state transition in embryonic stem cells”的研究论文，通过三维基因组测序等一系列...
浙江大学生命科学研究院2021年10月1日冯新华和金建平实验室联合在Cancer Research发文揭示AMBRA1调控TGF-β促癌信号的分子机制与功能（图）
冯新华 金建平 细胞增殖 胚胎发育
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2022/10/25
2021年10月1日，浙江大学生命科学研究院冯新华实验室和金建平实验室联合在Cancer Research（癌症研究）发表题为“AMBRA1 promotes TGF-β signaling via non-proteolytic polyubiquitylation of Smad4”的研究论文。转化生长因子β (Transforming Growth Factor-β, TGF-β) 在细胞增...
近日，医学部许兴智教授团队在《Nucleic Acids Research》（影响因子16.971）发表了题为“PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair”的原创研究成果。报道揭...
Opinion of Health Care Professionals towards Submitting a Research Article to a Journal
Indian medical research Indexed journal Impact factor Publication
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2015/7/10
There are no specific criteria to measure a journals quality, but indexation of a journal in a reputed database such as PubMed/Medline, SCOPUS, EMBASE etc, and whether the journal is having an impact ...
A qualitative study using traditional community assemblies to investigate community perspectives on informed consent and research participation in western Kenya
community-based research ethics Western Kenya
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2014/12/11
Background International collaborators face challenges in the design and implementation of ethical biomedical research. Evaluating community understanding of research and processes like informed conse...
Advances in the research on the biological effects of heavy-ion radiation
Advances in the research biological effects heavy-ion radiation
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2015/11/24
Advances in the research on the biological effects of heavy-ion radiation.
A Review of Consumer-provided Services on Assertive Community Treatment and Intensive Case Management Teams: Implications for Future Research and Practice
consumer-provider peer services assertive community treatment case management
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2014/11/10
Background—Assertive community treatment (ACT) is an evidence-based practice that provides intensive, in vivo services for adults with severe mental illness. Some ACT and intensive case management tea...
Strategic Opportunities in Sleep and Circadian Research: Report of the Joint Task Force of the Sleep Research Society and American Academy of Sleep Medicine
Sleep Circadian Research
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2017/3/10
Sleep and circadian timing are fundamental biological imperatives
in animals and humans, throughout the lifespan. These
biological systems can be challenged by pathology, individual
choices, and so...
Long-Term Impact of Caregiving and Metabolic Syndrome with Perceived Decline in Cognitive Function 8 Years Later: A Pilot Study Suggesting Important Avenues for Future Research
Caregiving Metabolic Syndrome Cognitive Decline
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2013/8/30
The chronic stress of caregiving has been associated with increased risk for cognitive decline and dementia. One theoretical model suggests that a group of risk factors known as the metabolic syndrome...
INTRODUCING WHO SPECIAL PROGRAM FOR RESEARCH AND TRAINING IN TROPICAL DISEASES
Research and training Public health WHO
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2010/1/5
After giving a brief account about the history of the special program, the objectives and scope of the special program have been discussed and the Iranian scientists and institutes for research and tr...
Background: While the results of genetic research have increased our medical knowledge, promoted health and treatment of illness, some unique ethical problems arise about this type of research. Geneti...
PRIOITIES IN MALARIA FIELD RESEARCH
Malaria control Malaria eradication Anti–malaria activities
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2009/12/29
After mentioning the main differences between malaria control and malaria eradication, it is suggested that all anti–malaria activities in Iran should be renamed as malaria control. Applied research i...