搜索结果: 106-120 共查到“生物学 mRNA”相关记录240条 . 查询时间(0.172 秒)
乙肝慢性感染与肝癌发生密切相关，我国肝癌患者绝大多数感染慢性乙肝，目前乙肝引发肝癌的机制普遍认为是慢性炎症、病毒X蛋白等因素。中科院微生物研究所孟颂东课题组李长菲、王彦中等人研究发现，乙肝病毒mRNA也可能参与慢性乙肝感染向肝癌的转化，大量表达冗余的病毒mRNA与肝细胞中的小RNA miR-122结合，以“海绵”吸附的方式抑制miR-122，进而导致miR-122靶基因PBF（PTTG1 bind...
中国科学院生物物理研究所等发现锌指抗病毒蛋白ZAP抑制mRNA表达新机制（图）
mRNA降解 埃博拉病毒 抗病毒蛋白ZAP
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2012/10/15
2012年9月28日，EMBO J.在线发表了中科院生物物理研究所高光侠实验室的最新研究成果，题为Translational repression precedes and is required for ZAP-mediated mRNA decay。该成果揭示了宿主抗病毒蛋白ZAP通过翻译抑制和促进mRNA降解两种方式抑制病毒mRNA表达，翻译抑制发生在mRNA降解之前，并为RNA降解所必须。...
Effects of Immune Stress on Performance Parameters, Intestinal Enzyme Activity and mRNA Expression of Intestinal Transporters in Broiler Chickens
Broilers Gene Expression Immune Stress Intestine Enzyme
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2016/5/10
Immune stress is the loss of immune homeostasis caused by external forces. The purpose of this experiment was to investigate the effects of immune stress on the growth performance, small intestinal en...
凡纳滨对虾Toll受体和溶菌酶mRNA组织表达的差异研究
凡纳滨对虾 Toll受体mRNA 溶菌酶mRNA 血淋巴 鳃
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2012/3/19
采用荧光定量PCR技术，检测了凡纳滨对虾不同组织（血淋巴、鳃、肌肉和肝胰腺）中Toll受体和溶菌酶mRNA的相对表达量。结果表明：凡纳滨对虾Toll受体和溶菌酶mRNA在不同组织间的表达量存在显著差异。Toll受体mRNA在各组织中的相对表达水平由高到低顺序依次为血淋巴>鳃>肌肉>肝胰腺。溶菌酶mRNA表达水平则依次为血淋巴>鳃>肌肉>肝胰腺，但血淋巴和鳃之间无显著差异。溶菌酶mRNA和Toll ...
中国明对虾卵黄蛋白原mRNA基因在卵巢和肝胰腺中都有表达。采用实时荧光定量PCR方法测定在卵巢不同发育时期卵巢和肝胰腺这两种组织的卵黄蛋白原mRNA的表达水平，提取组织总RNA，设计特异性引物进行荧光定量PCR扩增，对卵巢发育的各个阶段，卵原细胞增殖期、卵黄发生前期、初级卵黄发生期、次级卵黄发生期和消退期的卵黄蛋白原mRNA表达进行相对定量分析。结果表明：在卵巢中，卵黄蛋白原mRNA在前3个阶段随...
Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript
ribosome traffic, master equation, extremum current hypothesis, distance-headway,TASEP.
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2011/8/29
The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called translation. Ribosome may be regarded as a molecular motor for which the mRNA...
SNPs 能改变基因表达, 导致编码氨基酸突变, 影响蛋白质功能, 这是目前被密切关注的问题. 对此, 普遍认为蛋白质结构的变化源自氨基酸取代, 很少有人注意mRNA 结构变化的影响. 选取人类β珠蛋白基因HBB及其4 个突变体样本, 用动态延伸折叠方法构建mRNA二级结构, 从有关数据库获得它们的表达产物的二级结构. 分别对成熟mRNA 和蛋白质做突变前后的结构对比, 并进行mRNA-蛋白质相应...
2011年7月15日，国际学术期刊The Journal of Biological Chemistry正式发表了中科院上海生命科学研究院生化与细胞所胡红雨课题组的研究论文，阐明了异常谷氨酰胺延伸的亨廷顿蛋白和mRNA剪接因子HYPA相互作用的结构基础和生物学效应。
Molecular Characterization and Expression of LDHA and LDHB mRNA in Testes of Japanese Quail (Coturnix japonica)
Lactate Dehydrogenase Testes Lactate Isozymes Messenger RNA
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2016/5/6
The LDH isozymes are key catalysts in the glycolytic pathway of energy metabolism. It is well known that the distribution of the LDH isozymes vary in accordance with the metabolic requirements of diff...
Effect of Excessive Vitamin A on Alkaline Phosphatase Activity and Concentrations of Calcium-binding Protein and Bone Gla-protein in Culture Medium and CaBP mRNA Expression in Osteoblasts of Broiler Chickens
Vitamin A Broiler Chicken Calcium-binding Protein mRNA Expression Osteoblast Bone Gla-protein
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2016/5/6
This study was conducted to determine the effects of excess vitamin A on alkaline phosphatase (ALP) activity, contents of calcium-binding protein (CaBP), bone gla-protein (BGP) in culture medium and C...
为了深入了解精氨酸激酶基因的作用和寻求害虫防治新的分子靶标， 本研究采用RT-PCR和RACE技术， 从烟夜蛾Helicoverpa assulta脂肪体中克隆了精氨酸激酶cDNA序列， 命名为HassAK（GenBank登录号: HQ336337）， 并采用荧光定量PCR测定了HassAK基因在不同发育阶段（4龄幼虫第1天到化蛹第1天）、 不同组织（头部、 中肠、 脂肪体、 体壁和腹足）和不同温...
《自然》：研究揭示mRNA非编码功能（图）
自然 mRNA 非编码功能
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2010/7/7
由1962年诺贝尔生理学或医学奖获得者英国科学家克里克和美国科学家沃森提出的分子生物学中心法则认为，遗传信息是从DNA（脱氧核糖核酸）传递给mRNA（信使核糖核酸），再从mRNA传递给功能蛋白质，由此来完成遗传信息的转录和翻译过程的。
Expression of Prolactin Receptor mRNA after Melatonin Manipulated in Cashmere Goats Skin during Cashmere Growth
Prolactin Receptor Real-time RT-PCR Melatonin Prolactin Cashmere Fibre Cashmere Goats
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2016/5/5
The aim of this research was to investigate the dynamic changes of the level of total prolactin receptor (PRLR) mRNA and the short form prolactin receptor (S-PRLR) mRNA in skin of cashmere goats from ...
Effect of Quercetin on the Activity and mRNA Expression of Antioxidant Enzymes and Physiological Responses in Olive Flounder (Paralichthys olivaceus) Exposed to Cadmium
Antioxidant LPO Lysozyme Quercetin ROS Cadmium Olive Flounder
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2016/5/4
We investigated the antioxidant efficacy of quercetin (0% Diet 1, 0.25% Diet 2, and 0.5% Diet 3) pretreatment for 30 and 60 days in response to cadmium (Cd) toxicity in the olive flounder, and measure...
Imprinted Gene mRNA Expression during Porcine Peri-implantation Development
Imprinted Genes Peri-implantation mRNA Expression Early Development Pig
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2016/5/4
Imprinted genes are essential for fetal development, growth regulation, and postnatal behavior. However, little is known about imprinted genes in livestock. We hypothesized that certain putatively imp...