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Science亮点 | 利用LNP技术在体制造的瞬时CAR T如何修补“受伤的心脏”?(图)
心脏 T细胞 纤维细胞 活化蛋白
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2022/12/20
纤维化影响着数以百万计的心脏病患者,但目前抗纤维化疗法旨在限制纤维化进展,而并非在形成初始就对其进行重塑。为此,已有研究报道特异性消除活化成纤维细胞的嵌合抗原受体 (chimeric antigen receptor, CAR) T细胞可以作为心力衰竭的治疗方法【1】,但问题就在于CAR T细胞在体内的持久生命力。成纤维细胞活化是许多组织中正常伤口愈合过程的一部分,而持久的抗纤维化CAR T 细胞...
SINGLE-AND TWO-CHANNEL NOISE REDUCTION FOR ROBUST SPEECH RECOGNITION IN CAR
automatic speech recognition robustness car noise two-channel noise reduction
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2015/9/29
Hands-free operation of a mobile phone in car raises major challenges for acoustic enhancement algorithms and speech recognition engines. This is due to a degradation of the speech signal caused by re...
基于CAR-DEA方法的环境效率评价研究
数据包络分析 不期望产出 保证域 CAR-DEA
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2012/8/3
现有环境效率评价的DEA方法没有考虑多维偏好约束问题,即不同决策单元对不同期望产出和不期望产出的偏好不同. 以地区为例,不同地区对GDP、废水和废气赋予的权重偏好各不相同. 在这种情况下,由于各决策单元的偏好约束不同,形成多维偏好约束集,在传统DEA模型中容易出现无可行解现象. 针对这一问题,基于CAR-DEA方法,结合保证域理论,提出一种解决多维偏好约束集问题的环境效率评价模型. 采用中国工业系...
Piecewise linear car-following modeling
Car-following modeling Optimal control Variational formulations
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2011/9/23
Abstract: We present a traffic model that extends the linear car-following model as well as the min-plus traffic model (a model based on the min-plus algebra). A discrete-time car-dynamics describing ...
Design of Environmental Hardware in Car Alternator Testing System
Alternator Fixture Frequency Converter Hardware Motor System
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2011/12/16
In an automobile, a stable and durable alternator is extremely important. Based on the basic characteristics of the alternators now on the mainstream market, the hardware simulation method was used to...
Eta Car and Its Surroundings:the X-ray Diagnosis。
Dust Formation Events in Colliding Winds:An Application to Eta Car
Dust Formation Eta Car Colliding Winds
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2009/6/15
Dust Formation Events in Colliding Winds:An Application to Eta Car。
Tecnical Note: Analysis of non-regulated vehicular emissions by extractive FTIR spectrometry: tests on a hybrid car in Mexico City
non-regulated vehicular emissions extractive FTIR spectrometry hybrid car Mexico City
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2009/1/20
A methodology to acquire valuable information on the chemical composition and evolution of vehicular emissions is presented. The analysis of the gases is performed by passing a constant flow of a sam...
基于SVR和CAR的多维时间序列分析及其在生态学中的应用
多维时间序列 支持向量回归
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2007/12/10
摘要 基于支持向量回归(SVR)并融合带受控项的自回归模型(CAR),建立了一种既反映样本集动态特征又体现环境因子影响的非线性多维时间序列分析预测方法(SVR-CAR)。用一步预测法对两个生态学样本集的预测结果表明,SVR-CAR在所有参比模型中预测精度最高,并具结构风险最小、非线性、避免过拟合、泛化推广能力优异等诸多优点。SVR-CAR在生态学、农业科学、经济学等多维时间序列预测领域有较广泛的应...
采用选择激发研究光系统Ⅱ反应中心β-Car的物理特性
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2007/8/20
光系统Ⅱ反应中心包含有2个去镁叶绿素分子(Pheo),2个β胡萝卜素分子(β-Car)和6个叶绿素a分子(Chla).对反应中心的时间分辨荧光光谱表明,两个β-Car具有不同的吸收光谱,吸收峰分别为489 nm(Car489)和507 nm(Car507),Car489靠近吸收峰为667 nm和675 nm的叶绿素a(Chl a),它的主要功能是保护反应中心免受单态氧的破坏,而不能将激发能传递给光...
An Improved Car-Following Model for Multiphase Vehicular Traffic
Flow and Numerical Tests
car-following models density waves traffic flow
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2007/8/15
2006Vol.46No.2pp.367-373DOI:
An Improved Car-Following Model for Multiphase Vehicular Traffic
Flow and Numerical Tests
LI Zhi-Peng, GONG Xiao-Bo, and LIU Yun-Cai
Instit...
Car Deceleration Considering Its Own Velocity in Cellular Automata Model
cellular automaton traffic flow fundamental diagram
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2007/8/15
2006Vol.45No.1pp.113-116DOI:
Car Deceleration Considering Its Own Velocity in Cellular Automata Model
LI Ke-Ping
Key Laboratory of Intelligent Technologies and Systems o...