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2015年度盖伦奖揭晓
2015年 盖伦奖
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2015/11/23
美国盖伦奖日前揭晓。盖伦奖由法国药物学家Roland Mehl于1970年在法国创立,用以表彰杰出的新药发现,是药物研发领域的最高殊荣,盖伦奖包括最佳药品、最佳生物制品和最佳医疗技术三个奖项。
Before Ibuprofen can relieve your headache, it has to dissolve in your bloodstream. The problem is Ibuprofen, in its native form, isn’t particularly soluble. Its rigid, crystalline structures — ...
美国用转基因酵母造出止痛药(图)
美国 转基因酵母 止痛药
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2015/8/18
酵母不但能用来发面蒸馒头,也能用来制造止痛药。日前,发表在《科学》上的一项研究介绍了一种用转基因酵母生产吗啡类止痛药的方法。研究人员称,该法不但能将药物的生产周期从一年缩短到几天,还能将成本降低到传统方法的十分之一,未来技术成熟后,有望大幅降低相关药物的零售价格。
Model Could Help Counteract Poisoning from Popular Painkiller
Counteract Poisoning Popular Painkiller
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2015/7/13
New research could help reverse deadly side effects caused by excessive doses of the drug acetaminophen, the major ingredient in Tylenol and many other over-the-counter and prescription medicines.Rese...
When a new type of drug or therapy is discovered, double-blind randomized controlled trials (DBRCTs) are the gold standard for evaluating them. These trials, which have been used for years, were desig...
Pinpointing natural cancer drug's true origins brings sustainable production a step closer
natural cancer drug sustainable production step closer
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2015/6/18
For decades, scientists have known that ET-743, a compound extracted from a marine invertebrate called a mangrove tunicate, can kill cancer cells. The drug has been approved for use in patients in Eur...
Discovery paves way for homebrewed drugs, prompts call for regulation(图)
paves way homebrewed drugs call for regulation
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2015/5/25
Fans of homebrewed beer and backyard distilleries already know how to employ yeast to convert sugar into alcohol. But a research team led by UC Berkeley bioengineers has gone much further by completin...
常用药可刺激自身干细胞替代受损脑细胞(图)
常用药 自身干细胞 受损脑细胞
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2015/4/23
多发性硬化症会造成脑细胞受损,最近,由美国凯斯西储医学院领导的一个多机构小组通过实验,筛选出两种原用于缓解皮肤病的药物,能指令脑部干细胞逆转损坏的脑细胞。两种药都还有其它候选。这一成果也为其它神经失调疾病,如脑瘫、衰老性痴呆、视神经炎和精神分裂等带来了希望。相关论文在线发表于4月20日的《自然》杂志上。
阿尔茨海默氏症实验疗法初现疗效(图)
阿尔茨海默氏症 实验疗法 初现疗效
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2015/3/26
美国《纽约时报》报道称,在一项临床实验中采用的阿尔茨海默氏症疗法已初步显现出积极疗效。百健艾迪公司的研究人员近日公布了其开发的候选药物——aducanumab在早期阿尔茨海默氏症患者中的Ⅰ期临床实验疗效。
Structure-based Design Used as Tool for Engineering Deimmunized Biotherapeutics(图)
Design Used as Tool Deimmunized Biotherapeutics
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2015/3/4
In the first experimental use of algorithms that employ structure-based molecular modeling to optimize deimmunized drug candidates, Karl Griswold, PhD, and co-investigator Christopher Bailey-Kellogg, ...
Customized Soap Bubbles Set to Transform Drug and Vaccine Delivery
Soap Bubbles Transform Drug Vaccine Delivery
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2015/3/4
When University of Maryland Professors Philip DeShong and Daniel Stein began tagging soap bubbles with biomolecules, they had no idea this technology would one day be poised to cha...
美国科学家希望借干细胞靶向药物消灭癌症(图)
美国科学家 借干细胞靶 药物消灭癌症
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2015/1/27
Robert Weinberg是当今世界最有名的癌症生物学家之一,他在区分标志癌症发展的基因方面曾做出先驱工作。他见证过来来往往各种癌症疗法带来的希望。“无论好坏,我在这个领域已经工作了40年。但我们过去做过的许多工作已经在临床上被证明是没有用的。”如今迈入古稀之年,已是72岁高龄的他重新恢复了乐观。“这是我真正意义上第一次处于研发一种或多种有效试剂的岗位上,这些疗法将真正惠及癌症患者。”他说。
美国发现近30年首个新型抗生素
美国 近30年 新型抗生素
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2015/1/14
美国科学家发现了近30年来第一种新型抗生素,其可以杀死耐甲氧西林金黄色葡萄球菌(MRSA)等多种致命病原体。科学家认为,随着人类与细菌耐药性之间战争的不断升级,这一抗生素有望成为“游戏规则颠覆者”。西北大学的吉姆·里维斯领导的研究团队在近日出版的《自然》杂志上撰文指出,他们在缅因州的土壤内发现了这种名为Teixobactin的抗生素。在老鼠身上进行的研究表明,该抗生素对致命的MRSA细菌等具有非常...
Promising New Method Found for Rapidly Screening Cancer Drugs
Rapidly Screening Cancer Drugs
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2014/12/30
AMHERST, Mass. – Traditional genomic, proteomic and other screening methods currently used to characterize drug mechanisms are time-consuming and require special equipment, but now researchers led by ...
“There is a lot to be excited about,” said Brian Kennedy, PhD, CEO of the Buck Institute, who said treatments, given at doses comparable to those used in humans, extended lifespan an average of 15 per...