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Androulakis Machine learning approaches in promoter sequence analysis
Androulakis Machine learning promoter sequence analysis
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2009/12/24
Gene transcription is one of the main biological processes that govern an organism's response
to external stimuli. Understanding the mechanism of gene regulation offers an avenue with
which to mode...
Networks, Biology and Systems Engineering: A Case Study in Inflammation
Systems biology transcriptional regulation disease models inflammation
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2009/12/24
Biological systems can be modeled as networks of interacting components across multiple scales. A central problem in computational systems biology is to identify those critical components and the rule...
Extraction of Transcription Factor Networks via Globally Optimal Biclustering
Bi-clustering Transcription Network Reconstruction
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2009/12/24
We present an optimization-based framework for identifying and quantifying interactions transcription factor networks. We explore the availability of high-temporal resolution expression data using the...
A Mixed Integer Optimization Algorithm to Reverse Engineer Transcriptional Regulatory Networks
mixed-integer optimization gene regulation Engineer Transcriptional Regulatory Networks
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2009/12/24
A major goal in post-genomic era is to reverse engineer transcriptional regulatory networks. Advances in high-throughout technologies e.g. DNA microarrays coupled with the working knowledge on the con...
Circadian variations in liver gene expression: Relationships to drug action
Circadian variations liver gene expression drug action
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2009/12/24
Chronopharmacology is an important but under-explored aspect of therapeutics. Rhythmic
variations in biological processes can influence drug action, including pharmacodynamic
responses, due to ci...
On the potential for integrating gene expression and metabolic flux data
Systems biology gene expression metabolic flux modeling
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2009/12/24
Computational strategies, that integrate genomic-level information and metabolic flux data, have improved both prediction of metabolic fluxes and metabolic network identification. Due to the tight int...
Translational Potential of Systems-Based Models of Inlammation
Translational Potential Systems-Based Models Inlammation
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2009/12/24
A critical goal of translational research is to convert basic science to clinically relevant actions related to disease prevention, diagnosis, and eventually enable physicians to identify and evaluate...
Physics-driven CFD modeling of complex anatomical cardiovascular flows-a TCPC case study
Fontan operation Digital particle image velocimetry Flow instability Computational Fluid Dynamics
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2009/12/23
Recent developments in medical image acquisition combined with the latest advancements in numerical methods for solving the Navier-Stokes equations have created unprecedented
opportunities for develo...
In vitro flow analysis of a patient-specific intraatrial total cavopulmonary connection
vitro flow analysis patient-specific intraatrial total cavopulmonary connection
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2009/12/23
Understanding the hemodynamics of the total cavopulmonary connection may lead to further optimization of the connection design and surgical planning, which in turn may lead to improved surgical outcom...
Total cavopulmonary connection flow with functional left pulmonary artery stenosis:angioplasty and fenestration in vitro
Total cavopulmonary connection flow functional left pulmonary artery stenosis angioplasty
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2009/12/23
In our multicenter study of the total cavopulmonary connection (TCPC), a cohort of patients with long-segment left pulmonary artery (LPA) stenosis was observed (35%). The clinically recognized detrime...
Coupling pediatric ventricle assist devices to the Fontan circulation:simulations with a lumped-parameter model
pediatric ventricle assist devices Fontan circulation simulations lumped-parameter model
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2009/12/23
Simulations with a Lumped-Parameter Model In pediatric ventricular assist device (VAD) design, the process of matching device characteristics and dimensions to the relevant disease conditions poses a ...
Introduction of a new optimized total cavopulmonary connection
Introduction new optimized total cavopulmonary connection
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2009/12/23
Several variations of the total cavopulmonary connection (TCPC) have been investigated for favorable fluid mechanics and flow distribution. This study presents a hemodynamically optimized TCPC configu...
Neonatal aortic arch hemodynamics and perfusion during cardiopulmonary bypass
Neonatal aortic arch hemodynamics perfusion cardiopulmonary bypass
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2009/12/23
The objective of this study is to quantify the detailed three-dimensional (3D) pulsatile
hemodynamics, mechanical loading, and perfusion characteristics of a patient-specific
neonatal aortic arch du...
Comprehensive approach for motion and distortion correction in diffusion weighted MRI
Comprehensive approach motion and distortion correction diffusion weighted MRI
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2009/12/23
Comprehensive approach for motion and distortion correction in diffusion weighted MRI.
Correction of motion artifact in cardiac optical mapping using image registration
Correction motion artifact cardiac optical mapping image registration
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2009/12/23
Correction of motion artifact in cardiac optical mapping using image registration.