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The proliferation and differentiation of possible Leydig cell precursors in adult rats were studied after destruction of the existing Leydig cells with EDS or after daily treatment with hCG. After 2...
To elucidate the effects of sulpiride-induced (300 mg daily) long-term (64 days) hyperprolactinemia on basal and hCG-stimulated plasma testosterone (T), hCG was given to five normal men five times...
Adult, unilaterally cryptorchid rats were given a single subcutaneous injection of hCG. HCG treatment of 100 I.U. (but not 10 I.U.) resulted in a marked increase in intratesticular pressure (approxi...
The present study was performed to demonstrate the binding, mode of uptake, pathway and fate of iodinated human chorionic gonadotropin ([125I]hCG) by Leydig cells in vivo using electron microscope...
The temporal relationship between exposure to prolactin (PRL) and luteinizing hormone (LH) induction of LH receptors was investigated in hypophysectomized adult male rats. Testicular homogenate me...
The process of early testosterone (T) secretion and Leydig cell differentiation in humans was studied to explore the steroidogenic capacity of Leydig cell fibroblastic precursors. Seven cryptorchi...
To evaluate the influence of age, testicular capillary blood flow (TCBF) was measured, using the microsphere technique, in rats 3 to 24 months old, under basal conditions and after hCG stimulation (...
The effects of chronic treatment with hCG (100 I.U.s.c. every second day) on testicular morphology, LH receptor levels and concentration of steroid intermediates of the 4 and 5 biosynthetic pathwa...
The relationships among testicular vein and jugular vein concentrations of androgens and estrogens were studied in anesthetized stallions. Blood was sampled from a vein on the surface of the testis ...
Recent evidence in our laboratory suggests that the cause of idiopathic subfertility/infertility in breeding stallions may originate in the testes at the luteinizing hormone (LH) receptor or postr...
We have investigated the effect of acute immobilization (3 hours) stress on testicular steroidogenesis in the adult rat. Immobilization did not alter plasma luteizing hormone (LH) levels, but plas...
Testosterone secretion in mammals typically occurs in random pulses such that a single blood sample provides limited information on reproductive endocrine status. However, it has been shown in sever...
A 28-year-old man presented with a leiomyosarcoma of the spermatic cord after 3 weeks of increasingly painful swelling of the left upper hemiscrotum. The tumor was high-grade, Stage III pT2b N0 M0 (...

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