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Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. II. Quantitative and qualitative histopathology of the testis
1,3-dinitrobenzene male reproduction rat
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2009/2/23
This study determined the quantitative and qualitative histopathologic effects of a single oral dose of 1,3-dinitrobenzene (48 mg/kg) on the rat testis from 1 to 175 days postexposure. The testis was ...
Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. I. Sperm quality, quantity, and fertilizing ability
long-term sequelae 1,3-dinitrobenzene male reproduction rat
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2009/2/23
Groups of eight adult male rats were given a single oral dose of 0 or 48 mg/kg of 1,3-dinitrobenzene and sacrificed at 1, 2, 4, 8, 16, 24, 32, 72, and 175 days posttreatment. The groups killed at 17...
Response to acute hCG stimulation and steroidogenic potential of Leydig cell fibroblastic precursors in humans
acute hCG stimulation steroidogenic potential Leydig cell fibroblastic precursors humans
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2009/2/20
The process of early testosterone (T) secretion and Leydig cell differentiation in humans was studied to explore the steroidogenic capacity of Leydig cell fibroblastic precursors. Seven cryptorchi...
Acute experimental testicular torsion
Acute experimental testicular torsion contralateral testis
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2009/2/20
Other investigators have shown that chronic unilateral testicular torsion produces negative effects on the contralateral testis in experimental animals. In the present study, bilateral testicular we...
Acute hormonal changes following chemotherapy for Hodgkin's disease in man
Acute hormonal changes Hodgkin's disease man
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2009/2/19
Eleven men, aged 21 to 60 years, with Hodgkin's disease have been studied before, during, and after chemotherapy. Blood samples were obtained for hormone analyses. In all 11 patients FSH levels rose...
The Effect of Acute and Chronic Ethanol Administration on Prolactin Secretion in Male Rats
ethanol prolactin glutamate decarboxylase
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2009/2/19
The effect of acute and chronic administration of ethanol on prolactin secretion in male rats was investigated under basal conditions and after the administration of sulpiride. The effect of ethan...
Effect of acute androgen withdrawal by GnRH antagonist on epididymal sperm motility and morphology in the cynomolgus monkey
acute androgen withdrawal GnRH epididymal sperm motility
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2009/2/18
Hormonal male contraception requires an induction phase before azoospermia and contraceptive safety are achieved. The nature of spermatozoa that may be ejaculated during this induction phase was s...
Acute effects of spinal cord injury on the pituitary-testicular hormone axis and Sertoli cell functions：a time course study
spinal cord injury pituitary-testicular hormone axis Sertoli cell functions
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2009/2/13
The present study investigated the time course of the onset of the abnormalities in spermatogenesis following spinal cord injury, and their relationship to changes in the pituitary testicular hormon...
Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors
Stress rats testosterone 17a-hydroxylase
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2009/2/12
We have investigated the effect of acute immobilization (3 hours) stress on testicular steroidogenesis in the adult rat. Immobilization did not alter plasma luteizing hormone (LH) levels, but plas...
Acute and long-term effects of a single dose of the fungicide carbendazim（methyl 2-benzimidazole carbamate）on the male reproductive system in the rat
fungicide carbendazim（methyl 2-benzimidazole carbamate） male reproductive system rat
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2009/2/11
The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rat after a single oral dose. Two experimental trials were perf...
Acute and chronic effects of cisplatinum upon testicular function in the rat
cisplatinum testis spermatogenesis Sertoli cell seminal vesicle
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2009/2/6
One of the side effects of cisplatinum-based chemotherapy is the impairment of spermatogenic function. In order to understand the mechanisms responsible for this side effect, the present study exami...
Effects of short-term stimulation of serotoninergic pathways on the pulsatile secretion of luteinizing hormone in the absence and presence of acute opiate-receptor blockage
pulsatile gonadotropin secretion serotonin
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2009/2/6
To investigate the role of the serotoninergic system in regulating pulsatile gonadotropin secretion in man, we tested the influences of a novel selective serotonin re-uptake inhibitor (fluoxetine HC...
Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells
Melatonin inhibits steroidogenic protein steroidogenesis MA-10 cells
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2008/12/26
The effects of melatonin on steroidogenesis and steroidogenic acute regulatory (StAR) protein expression were investigated in MA-10 mouse Leydig tumor cells. MA-10 cells were treated with human chorio...
Leydig cell aging：steroidogenic acute regulatory protein（StAR）and cholesterol side-chain cleavage enzyme
Leydig cell aging protein（StAR） cholesterol side-chain cleavage enzyme
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2008/12/26
Primary points of control in steroidogenesis are the transport of cholesterol from intracellular stores to the inner mitochondrial membrane, and the subsequent conversion of cholesterol to pregnenolon...
Acute Adverse Effects of the Indenopyridine CDB-4022 on the Ultrastructure of Sertoli Cells, Spermatocytes, and Spermatids in Rat Testes：Comparison to the Known Sertoli Cell Toxicant Di-n-pentylphthalate（DPP）
Antifertility morphology ultrastructure seminiferous epithelium germ cells
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2008/12/24
Acute effects of CDB-4022 on testicular ultrastructure were determined. Rats were treated orally with vehicle or a maximally effective single dose of CDB-4022 or Di-n-pentylphthalate (DPP). Prese...