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Redox Biology│北京大学第一医院黄娅茜和金红芳课题组发现内源性二氧化（图）
北京大学第一医院 儿童医学中心 生物学
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2024/7/11
2024年3月，北京大学第一医院儿童医学中心黄娅茜和金红芳课题组在国际生物学领域权威期刊《Redox Biology》（IF:11.4）在线发表了题为“Endogenous sulfur dioxide deficiency as a driver of cardiomyocyte senescence through abolishing sulphenylation of STAT3 at c...
近日，中南大学湘雅医院麻醉手术部黄长盛教授团队在氧化应激领域国际著名期刊《Redox Biology》(中科院一区TOP 期刊，IF： 10.787) 发表原创学术论文“Inhibition of Spinal Ferroptosis-like Cell Death Alleviates Hyperalgesia and Spontaneous Pain in a Mouse Model of B...
2023年3月21日，中南大学湘雅医院眼科中心/眼科学湖南省重点实验室夏晓波教授团队在在氧化应激领域国际顶级期刊《Redox Biology》（中科院一区Top期刊，IF：10.787）发表原创学术论著“Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads ...
Redox Biology：G蛋白β5-atm复合物驱动扑热息痛肝毒性
Redox Biology G蛋白 β5-atm复合物 扑热息痛 肝脏毒
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2021/5/13
印度桑贾伊·甘地医学研究生院在“Redox Biology”杂志发表了题为G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity的文章。G蛋白β5-atm复合物驱动扑热息痛肝毒性。该研究为Gβ5在肝脏中的新的、非G蛋白依赖的作用提供了一个可行的解释。G-β5在导致急性胰腺炎依赖性肝损伤的多种病理后遗症中处于关键节点...
附属北京妇产医院阴赪宏教授团队《Redox Biol》揭示tempol对多囊卵巢综合征的保护作用及分子机理（图）
首都医科大学附属北京妇产医院 阴赪宏教授 Redox Biol tempol 多囊卵巢综合征 保护 分子机理
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2021/3/11
2021年2月，首都医科大学附属北京妇产医院阴赪宏教授团队在氧化应激和自由基领域的权威杂志《Redox Biology》上发表题为“Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composit...
扩张型心肌病（dilated cardiomyopathy，DCM）是一类以左心室/两心室扩张、收缩力受损为特征的心肌疾病，是心力衰竭的常见病因，患者5年存活率仅有50%，目前缺乏有效治疗手段，对于终末期心衰的DCM患者，心脏移植是唯一的治疗方法，然而在实际操作中，供体缺乏是难以解决的问题。因此，探讨DCM发病机制、寻找新的防治靶点尤为重要。3月30日，中山大学中山医学院谭红梅教授与中山大学附属第...
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
APE1 DNA repair hematopoiesis
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2014/12/12
Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice, embryos do not survive beyond embryonic day 9, indicating that this molecule...
Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation
APE/Ref-1 reactive oxygen species redox
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2014/12/12
Reactive oxygen species (ROS) arise through normal cellular aerobic respiration, and, in combination with external sources such as ionizing radiation, cigarette tar and smoke, and particulate matter g...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
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2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation
Ref-1 DNA-binding activity signaling
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2014/12/12
The Ref-1 (also called APE or HAP1) protein is a bifunctional enzyme impacting on a wide variety of important cellular functions. It acts as a major member of the DNA base excision repair pathway. Mor...
Evolution of the redox function in mammalian Apurinic/ apyrimidinic endonuclease
APE1 redox evolutionary analysis
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2014/12/12
Human apurinic/apyrimidinic endonuclease (hApe1) encodes two important functional activities: an essential base excision repair (BER) activity and a redox activity that regulates expression of a numbe...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
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2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...