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Researchers discover neuronal targets that restore movement in Parkinson's disease model
Researchers neuronal targets restore movement Parkinson's disease model
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2017/7/20
Researchers working in the lab of Carnegie Mellon University neuroscientist Aryn Gittis have identified two groups of neurons that can be turned on and off to alleviate the movement-related symptoms o...
Gordon Research Conference on Mechanisms of Epilepsy & Neuronal Synchronization
Epilepsy Neuronal S
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2016/7/29
The main goal of the study of seizures is to identify the mechanisms underlying synchronous electrical discharges in neuronal networks – in order to develop more effective treatments and cures for epi...
Novel regulation of neuronal genes implicated in Alzheimer disease by microRNA
Alzheimer APP BACE1 microRNA post-transcriptional gene regulation amyloid fetal neurons
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2015/5/21
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β peptide (Aβ) as neuritic plaques in the brain. The short Aβ peptide is derived from a large transmembrane precurs...
The effects of CaMKII signaling on neuronal viability
Calcium/calmodulin-dependent protein kinase II CaMKII Neuron Neurotransmitter Neurotoxicity
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2015/5/21
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a critical modulator of synaptic function, plasticity, and learning and memory. In neurons and astrocytes, CaMKII regulates cellular excitabi...
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
DNA repair gene therapy
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2014/12/12
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...
Reactive oxygen species induced oxidative stress, neuronal apoptosis and alternative death pathways
Apoptosis Caspases Cell Death Mitochondria PCBs Reactive Oxygen Species
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2013/1/28
Reactive oxygen species (ROS) are produced as a byproduct of cellular metabolic pathways and function as a critical second messenger in a variety of intracellular signaling pathways. The excessive int...
Neuronal protection by a variant of GAPDH pseudogene P44 in AD
GAPDH, Alzheimer’s Disease Pseudogene GAPDHP44 SNP
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2013/1/28
GAPDH is a conserved enzyme that binds diverse proteins, such as Siah during apoptotic nuclear translocation. There is one somatic GAPDH gene, but over 60 pseudogenes, the expression of which is nebul...
Early Exposure to Environmental Toxin Contributes to Neuronal Vulnerability and Axonal Pathology in a Model of Familial ALS
SOD1 ALS Neurotoxin Axonopathy NMJ Gliosis Toxicity
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2013/1/30
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons. Sporadic ALS causa...
The spatial and temporal relationship between oxidative stress and neuronal degeneration in 3-nitropropionic acid model
Energy Impairment 3-Nitropropionic Acid Oxidative Stress Neurodegeneration
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2013/2/20
The current study investigates the role of oxidative stress and calcium homeostasis in the development of selective striatal lesions in metabolic impairment model caused by 3-nitropropionic acid (3NP)...
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
vitamin C cyclooxygenase-2 oxidative stress Alzheimer’s disease stroke reactive oxygen species neuroinflammation NSAIDs 8-isoprostanes prostaglandin E synthase
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2015/8/3
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathop...
Neuronal Migration Disorder;A Case Report of Subcortical Band Heterotopia Associated with Corpus Callosum Agenesis
Subcortical Band Heterotopia Corpus Callosum Agenesis Neuronal Migration Disorder Seizure Child
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2009/12/7
Subcortical band heterotopia (SBH) or 'double cortex' is a congenital brain abnormality that results from aberrant migration of neurons during development of the cortex. MRI shows a continuous band of...
Neuronal Differentiation in The Cerebral Cortex of The Rat: A Golgi-Cox Study
Development cerebral cortex neuron rat
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2009/7/2
The development of cerebral cortex neurons has been studied in different stages of pre- and postnatal periods of rats. In order to show the neuronal processes, the Golgi-Cox impregnation technique was...
Quantitation of Neuronal Loss Induced by Status Epilepticus and the Effects of Nitric Oxide
Lithium-pilocarpine tatus epilepticus L-Arginine -NAME Neuron loss
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2009/6/30
Neuronal loss in the hippocampal CA1 and CA3 fields due to lithium-pilocarpine- induced status epilepticus (SE) and the effects of a nitric oxide (NO) substrate, L-Arginine and a NO synthase inhibitor...
Voltage sensitive dye imaging of transient neuronal assemblies in brain slices under hyperbaric conditions
voltage sensitive dye pressure-reversal Brain slices animal rat
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2009/6/2
We have developed a high pressure optical cell to study large-scale transient neuronal coalitions--"assemblies" using voltage sensitive dye (VSD) fluorescence combined with fast CCD imaging of brain s...
The Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Rats
Zinc cell death hippocampus 7-nitroindazole stereology rat
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2009/5/20
Aim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4·7H2O) treatment. Materials an...