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Level of DNA Damage in Lead-Exposed Workers
lead comet assay DNA damage occupational exposure
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2010/12/22
Lead plays a significant role in modern industry. This metal is related to a broad range of physiological, biochemical and behavioural dysfunctions. The genotoxic effects of lead have been studied bot...
Study of DNA damage induced by dental bleaching agents in vitro
CHO cells Comet assay Tooth bleaching Mutagenicity tests
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2009/10/19
Dental bleaching is a simple and conservative procedure for aesthetic restoration of vital and non-vital discolored teeth. Nevertheless, a number of studies have demonstrated the risk of tissue damage...
A Preliminary Study of DNA Damage in Peripheral Lymphocytes from Lung Cancer Patients and Healthy Subjects
Comet assay DNA damage Lung cancer Lymphocyte
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2009/6/24
A pilot study was undertaken to investigate the differences in oxidative DNA damage and 2-h DNA repair in peripheral lymphocytes between lung cancer patients and healthy subjects. Twenty-four lung ca...
Genetic Studies of Bone Diseases: Evidence for Involvement of DNA Damage Response Proteins in Bone Remodeling
p53 Atm c-Abl osterix osteoblast osteoporosis
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2009/4/20
Bone remodeling is carried out by bone marrow mesenchymal stem cell derived osteoblasts, which form the bones, and hematopoeitic stem cell derived osteoclasts, which absorb the bones. Their actions a...
Localization of oxidative DNA damage after Au injection and effects of Au on Cp in renal kidney
Gold (Au) Copper (Cu) Ceruloplasmin (Cp) 8-hydroxydeoxyguanosine (8-OHdG) Metallotionein (MT)
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2009/4/1
The present study was carried out to investigate the effect of gold (Au) injection on copper (Cu) and two types of ceruloplasmin (Cp), total Cp (ID1) and active Cp (ID2), metallothionein (MT) in the s...
Mechanisms of the DNA Damage in Rat Kidney after Au Injection
Gold (Au) Copper (Cu) 8-hydroxydeoxyguanosine (8-OHdG) DNA damage Metallothionein (MT)
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2009/3/16
Au (gold) is a heavy metal and its complexes are one of the more effective medicaments available for rheumatoid arthritis, although many authors have reported serious kidney damage during the chrysoth...
Evaluation of oxidative DNA damage in human sperm and its association with male infertility
8-Hydroxydeoxyguanosine spermatozoa infertility
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2009/2/18
Recently, there is increasing evidence suggesting that oxidative sperm DNA damage is closely associated with impaired sperm function and male infertility. 8-Hydroxydeoxyguanosine (8-OHdG) is consi...
An immunochemical assay to detect DNA damage in bovine sperm
immunochemical assay DNA damage bovine sperm
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2008/12/25
An immunochemical assay has been developed to detect oxidative damage in bovine sperm DNA. Sperm DNA contains a large amount of oxidative damage as a result of exposure to exogenous agents, but dama...
DNA Damage in Bovine Sperm Does Not Block Fertilization and Early Embryonic Development But Induces Apoptosis After the First Cleavages
Mitotic spindles blastocyst ICSI
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2008/12/23
The main goal of this study was to investigate whether and at what level damage of paternal DNA influences fertilization of oocytes and early embryonic development. We hypothesized that posttesticul...
Nickel-Induced Oxidative Stress in Testis of Mice：Evidence of DNA Damage and Genotoxic Effects
Nickel chloride oxidative damage apoptosis abnormal sperms dominant lethal mutations
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2008/12/22
Oxidative stress (OS) mechanisms are speculated to play a significant role in nickel-induced toxic effects and their carcinogenic potency. Although nickel-induced oxidative damage in somatic tissues...
Spermiogenic Germ Cell Phase–Specific DNA Damage Following Cyclophosphamide Exposure
Sperm comet assay chromatin remodeling susceptibility toxicology
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2008/12/22
The production of genetically competent spermatozoa is essential for normal embryo development. The chemotherapeutic drug cyclophosphamide creates cross-links and DNA strand breaks in many cell type...
Cryopreservation of Ram Semen Facilitates Sperm DNA Damage: Relationship Between Sperm Andrological Parameters and the Sperm Chromatin Structure Assay
Artificial insemination semen quality motility chlortetracycline viability SCSA
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2008/12/22
We hypothesized that cryopreservation and incubation in conditions that mimic the female genital tract following insemination increases the susceptibility of ram sperm DNA to denaturation. Ram spe...
Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults1,2,3
Watercress cruciferous vegetables DNA damage antioxidants humans cancer biomarkers
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2008/12/9
Background: Cruciferous vegetable (CV) consumption is associated with a reduced risk of several cancers in epidemiologic studies.Objective: The aim of this study was to determine the effects of waterc...
Detection of DNA damage in response to cooling injury in equine spermatozoa using single-cell gel electrophoresis
DNA damage equine spermatozoa single-cell gel electrophoresis
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2008/12/1
Single-cell gel electrophoresis (SCGE), or comet assay, has the ability to detect damage at the single cell level and has not been reported for equine sperm. The ability to detect nuclear damage at ...
Oxidative DNA damage in human white blood cells in dietary antioxidant intervention studies
Antioxidants comet assay humans intervention studies 7-hydroxy-8-oxo-2′-deoxyguanosine oxidative DNA damage vitamin C vitamin E carotenoids
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2016/12/19
Many epidemiologic studies have addressed the possible preventive effects of antioxidants in disease causation and progression. With the use of molecular techniques, it is feasible to investigate spec...