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MIT neuroscientists have found a way to reverse neurodegeneration and other symptoms of Alzheimer’s disease by interfering with an enzyme that is typically overactive in the brains of Alzheimer’s pati...
NOVEL STRATEGIES TO MODULATE SYNAPTIC COMMUNICATION AND INVESTIGATE THE ROLE OF HDAC6 IN ALZHEIMER’S DISEASE
Photochemistry GABA_A receptors Alzheimer's disease Tau HDAC6
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2014/12/10
Neuronal communication is mediated by chemical signaling at the synapse. The underlying molecular mechanisms of learning and memory are poorly understood. Very few tools are available to study how mem...
蛋白磷酸酯酶对Alzheimer神经原纤维缠结的松解作用
Ａｌｚｈｅｉｍｅｒ病 蛋白磷酸酯酶 神经原纤维缠结 去磷酸化作用
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2007/12/18
摘要 神经原纤维缠结是Ａｌｚｈｅｉｍｅｒ患者的特征性脑病理损伤，其形成机制至今不明．根据神经原纤维缠结的基本组分是异常磷酸化ｔａｕ蛋白的聚集形式双螺旋丝（ｐａｉｒｅｄｈｅｌｉｃａｌｆｉｌａｍｅｎｔｓ，ＰＨＦ）的研究结果，推测蛋白磷酸酯酶与蛋白激酶的失衡可能与ＰＨＦ的形成有关．将蛋白磷酸酯酶ＰＰ－２Ａ和ＰＰ－２Ｂ与ＰＨＦ一起在３７℃保温３０ｍｉｎ可使ＰＨＦ缠结结构松解，成为单个ＰＨＦ原纤维，延长去磷...
专著信息
书名
A new strategy to combat Alzheimer’s disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule
语种
英文
撰写或编译
作者
Hong-Fang Ji,Hong-Yu Zhang
第一作者单位
出版社...
UC San Diego Supercomputer Simulations May Pinpoint Causes of Parkinson’s, Alzheimer’s Diseases
Supercomputer Parkinson’s disease Alzheimer’s disease
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2007/3/26
March 19, 2007，Using the massive computer-simulation power of the San Diego Supercomputer Center (SDSC) at UC San Diego, researchers are zeroing in on the causes of Parkinson’s disease, Alzheimer’s di...