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Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
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2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
Down syndrome mouse models EGCG development Dyrk1a
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2015/5/22
Down syndrome (DS) is the result of trisomy of human chromosome 21 (Hsa 21) and occurs in approximately 1/700 live births. Mouse models of DS have been crucial in understanding the gene-phenotype rela...
Developmental Differences and Altered Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
development craniofacial dysmorphology mouse model Down syndrome
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2015/5/22
Trisomy 21 occurs in approximately 1 out of 750 live births and causes brachycephaly, a small oral cavity, a shortened mid-face, and mental impairments in individuals with Down syndrome (DS). Craniofa...