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Anew genetic variant that protects against Alzheimer’s disease has been identified by an international team led by Harvard Medical School investigators at Massachusetts General Hospital and Massachuse...
MIT neuroscientists have found a way to reverse neurodegeneration and other symptoms of Alzheimer’s disease by interfering with an enzyme that is typically overactive in the brains of Alzheimer’s pati...
The following press release was issued today by the Broad Institute of MIT and Harvard.
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease（图）
阿尔茨海默病 交叉细分 单细胞分析 脑细胞
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2023/6/21
After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But in a new review articl...
Alzheimer’s risk gene undermines insulation of brain’s “wiring”（图）
阿尔茨海默氏症 风险基因 APOE4 脑细胞 隔离神经元
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2023/6/21
It’s well-known that carrying one copy of the APOE4 gene variant increases one’s risk for Alzheimer’s disease threefold and two copies about tenfold, but the fundamental reasons why, and what can be d...
近日，山西医科大学基础医学院细胞生理学教育部重点实验室祁金顺教授团队与贺培凤教授带领的健康大数据团队进行的校内合作成果，在国际阿尔茨海默病协会（ADI）会刊《Alzheimer's Research & Therapy》（中科院期刊分区2区，影响因子：6.116）发表了题为《Trichostatin A ameliorates Alzheimer's disease-related patholo...
Neurons stripped of their identity are hallmark of Alzheimer's disease, study finds（图）
Neurons stripped hallmark Alzheimer disease
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2020/11/20
Researchers at the University of California San Diego have identified new Alzheimer's disease mechanisms in neurons. The scientists have discovered that changes in the structure of chromatin...
Predicting Alzheimer's-like memory loss before it strikes（图）
Predicting Alzheimer's-like memory loss before it strikes
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2019/12/6
For someone with Alzheimer's disease, there's no turning back the clock. By the time memory loss and other worrisome signs appear, cognitive decline has already begun.Now, NSF-funded researchers at Gl...
A probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide — the kind suspected of causing Alzheimer’s disease — has identified a specific binding site on the...
Researchers Find Pathologic Hallmarks of Alzheimer’s Disease In Aged Chimpanzee Brains（图）
Researchers Pathologic Hallmarks Alzheimer’s Disease Aged Chimpanzee Brains
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2017/9/4
The brains of aged chimpanzees, our closest living relatives, show pathology similar to the human Alzheimer’s disease (AD) brain, according to a new, multi-institution research study.The findings, in ...
Kent State Researchers Help Find Pathologic Hallmarks of Alzheimer’s Disease in Aged Chimpanzee Brains（图）
Kent State Researchers Pathologic Hallmarks Alzheimer’s Disease Aged Chimpanzee Brains
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2017/9/1
Dementia affects one-third of all people older than 65 years in the United States. The most common cause of dementia is Alzheimer’s disease, a progressive, irreversible brain disease that results in i...
Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study
Alzheimer disease apolipoprotein E4 cholesterol cognitive function,
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2018/11/12
Background: There is little information about the associations of intakes of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline in general populations or i...
NOVEL STRATEGIES TO MODULATE SYNAPTIC COMMUNICATION AND INVESTIGATE THE ROLE OF HDAC6 IN ALZHEIMER’S DISEASE
Photochemistry GABA_A receptors Alzheimer's disease Tau HDAC6
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2014/12/10
Neuronal communication is mediated by chemical signaling at the synapse. The underlying molecular mechanisms of learning and memory are poorly understood. Very few tools are available to study how mem...
Pathways to dementia: genetic predictors of cognitive and brain imaging endophenotypes in Alzheimer's disease
Episodic memory Amyloid plaque
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2015/5/21
Alzheimer's disease (AD) is a national priority, with nearly six million Americans affected at an annual cost of $200 billion and no available cure. A better understanding of the mechanisms underlying...
Scientists identify molecular trigger for Alzheimer’s disease
Scientists identify molecular trigger Alzheimer’s disease
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2013/5/27
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer’s disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of...