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The Utility of Optical Loupe Magnification for Testis Sperm Extraction in Men With Nonobstructive Azoospermia
Male infertility intracytoplasmic sperm injection
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2008/12/23
The testis of patients with nonobstructive azoospermia (NOA) harbors sperm in approximately 30% to 60% of cases. Use of an operating microscope has been shown to result in better sperm retrieval rat...
Activation of the Nuclear Factor Kappa B Pathway Following Ischemia-Reperfusion of the Murine Testis
Testicular oxidative stress apoptosis NF-B activation
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2008/12/23
Ischemia-reperfusion (IR) of the testis results in testicular oxidative stress and germ cell-specific apoptosis. Nuclear factor kappa B (NF-B) is a nuclear transcription factor involved in the control...
From the XXVII North American Testis Workshop：The Function of SMC and Other Cohesin Proteins in Meiosis
Function SMC Cohesin Proteins Meiosis
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2008/12/22
To develop into haploid gametes, germ cells must undergo meiosis, a 2-step cell division process that is characterized by a sophisticated design in chromosome architecture and highly specific dynamic ...
Nickel-Induced Oxidative Stress in Testis of Mice：Evidence of DNA Damage and Genotoxic Effects
Nickel chloride oxidative damage apoptosis abnormal sperms dominant lethal mutations
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2008/12/22
Oxidative stress (OS) mechanisms are speculated to play a significant role in nickel-induced toxic effects and their carcinogenic potency. Although nickel-induced oxidative damage in somatic tissues...
A Game of Cat and Mouse: Xenografting of Testis Tissue From Domestic Kittens Results in Complete Cat Spermatogenesis in a Mouse Host
Sperm testis grafting felid species preservation
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2008/12/22
Loss of genetic diversity because of infertility or the premature death of valuable individuals is a significant problem in the conservation of rare and endangered felid species, as well as in the m...
Evidence for the Presence of Angiogenin in Human Testis
Immunohistochemistry in situ hybridization
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2008/12/22
We have reported the expression and possible roles of angiogenin, a potent angiogenic factor, in human female reproductive organs. In this study, we investigated the expression of angiogenin in the ...
Expression of a Novel RAD23B mRNA Splice Variant in the Human Testis
RAD23 alternative splice ubiquitin spermatogenesis proteolysis self-balance
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2008/12/22
A gene coding a novel human RAD23B protein named RAD23-like protein B, presumably involved in spermatogenesis, was identified and characterized using a complementary DNA (cDNA) microarray. In the hu...
Primary Carcinoid Tumor of the Testis Found at the Time of Elective Sterilization
Primary Carcinoid Tumor Testis Elective Sterilization
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2008/12/22
Carcinoid tumor of the testis can occur as a primary neoplasm or as metastases. This tumor accounts for less than 1% of all testicular neoplasms, with 1.1%–3.1% of cases associated with carcinoid ...
Heat-Induced Apoptosis of Mouse Meiotic Cells Is Suppressed by Ectopic Expression of Testis-Specific Calpastatin
ldhc gene tCAST cell death calpain spermatocytes
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2008/12/22
Calpastatin is a naturally occurring inhibitor of calpain, a protease involved in apoptotic cell death. A testis-specific isoform of calpastatin (tCAST) has been identified that is transcribed in ...
Cell Specificity of Aquaporins 0, 3, and 10 Expressed in the Testis, Efferent Ducts, and Epididymis of Adult Rats
Water transport Sertoli basal nonciliated androgens
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2008/12/22
Aquaporins (AQPs) are transmembrane protein channels that allow the rapid passage of water across an epithelium at a low energy requirement, though some also transport glycerol, urea, and solutes ...
Zyxin, Axin, and Wiskott-Aldrich Syndrome Protein Are Adaptors That Link the Cadherin/Catenin Protein Complex to the Cytoskeleton at Adherens Junctions in the Seminiferous Epithelium of the Rat Testis
Sertoli cells testis adaptors
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2008/12/22
During spermatogenesis, the movement of germ cells across the seminiferous epithelium is associated with extensive junction restructuring. Yet the underlying mechanism (or mechanisms) that regulates...
Functional Analysis of the Cooled Rat Testis
Spermatogonia testis apoptosis cooling transplantation
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2008/12/22
Direct cooling of the testis results in the depletion of most germ cells in vivo. Germ cell-depleted testes are now commonly used to investigate spermatogenic regeneration and can serve as recipient...
High Levels of Sperm DNA Denaturation as the Sole Semen Abnormality in a Patient After Chemotherapy for Testis Cancer
Sperm DNA Denaturation Sole Semen Abnormality Patient Chemotherapy Testis Cancer
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2008/12/19
Systemic chemotherapy for the treatment of cancer is known to adversely affect male fertility potential. Sperm DNA damage is reported after cancer chemotherapy and is associated with semen 0abnormalit...
Abundance of Repetitive Sequence Elements in the Mouse Testis-Specific Lactate Dehydrogenase-C Gene1
Isozyme restriction maps
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2008/12/19
We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene. The 2 genes were found to be oriented in head-to-tail fashion with about a 6-ki...
A Transgenic Analysis of Mouse Lactate Dehydrogenase c Promoter Activity in the Testis
Transcription mRNA stability protein stability
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2008/12/19
Transcription of the mouse testis-specific lactate dehydrogenase c (mldhc) gene is limited to cells of the germinal epithelium. Cloning and analysis of the mldhc promoter revealed that a 100-bp co...