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Effects of Maternal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-Hexachlorobiphenyl (PCB169) on Testicular Steroidogenesis and Spermatogenesis in Male Offspring Rats
PCB androgen pituitary
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2008/12/23
On days 7-21 of gestation, Sprague-Dawley rats were orally administered 3 or 30 µg/kg/d of 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) daily. Their m...
Rho-kinase Inhibition Improves Erectile Function in Aging Male Brown-Norway Rats
Muscle smooth drug effects penis physiology biological aging penile erection
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2008/12/23
Physiological aging is a significant risk factor in the on-set of male erectile dysfunction (ED) and an imbalance in factors that modulate cavernosal smooth-muscle tone may play a role in these altere...
Restoration of Erectile Capacity in Normotensive Aged Rats by Modulation of Angiotensin Receptor Type 1
Erectile dysfunction Sprague-Dawley rat losartan
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2008/12/23
We investigated the effects of systemic modulation of angiotensin 2 on the erectile dysfunction of aged rats. Young and aged (18 months old) male Sprague-Dawley rats were either treated with daily a...
Permanent Induction of Morphological Abnormalities in the Penis and Penile Skeletal Muscles in Adult Rats Treated Neonatally With Diethylstilbestrol or Estradiol Valerate：A Dose-Response Study
Estrogen DES fertility testosterone bulbocavernosus
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2008/12/22
This study evaluated the effects of neonatal exposure to different doses of diethylstilbestrol (DES) or estradiol valerate (EV) on penile morphology, penile skeletal muscles, and fertility. Male pup...
Comparison of Tamoxifen and Testosterone Propionate in Male Rats：Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone–IGF-I Axis
Testis androgens estrogens aromatase osteoporosis prostate seminal vesicle
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2008/12/22
Testis dysfunction can weaken bone and reduce muscle mass as well as impair sexual function. Testosterone (T) therapy has useful effects on sex organs, bone, and muscle in T-deficient males, but pro...
Cell Specificity of Aquaporins 0, 3, and 10 Expressed in the Testis, Efferent Ducts, and Epididymis of Adult Rats
Water transport Sertoli basal nonciliated androgens
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2008/12/22
Aquaporins (AQPs) are transmembrane protein channels that allow the rapid passage of water across an epithelium at a low energy requirement, though some also transport glycerol, urea, and solutes ...
Preservation of Spermatogenesis in Spinal Cord Injured Rats With Exogenous Testosterone. Relationship With Serum Testosterone Levels and Cellular Localization of cAMP Responsive Element Modulator
Sertoli cells CREM sperm
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2008/12/22
The current experiment examined the effects of exogenous testosterone (T) on spermatogenesis in rats with spinal cord injury (SCI) and their relationship with the cellular distribution of a cyclic AMP...
Smooth Muscle Cell Behavior in the Ventral Prostate of Castrated Rats
Androgen castration SEM stereological analysis smoothelin smooth muscle myosin
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2008/12/22
Smooth muscle cells (SMC) play roles in prostatic development and function. The cells also respond to tissue injury and hormonal variations, alternating between a fully differentiated and contractil...
Neonatal Coadministration of Testosterone With Diethylstilbestrol Prevents Diethylstilbestrol Induction of Most Reproductive Tract Abnormalities in Male Rats
Rete testis efferent ducts vas deferens seminal vesicles androgens estrogens
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2008/12/19
The primary purpose of this study was to evaluate whether the coadministration of testosterone (TE; 200 µg) with 10 µg of diethylstilbestrol (DES) between days 2 and 12 postnatally could...
Rapid Proliferation of Prostatic Epithelial Cells in Spontaneously Hypertensive Rats: A Model of Spontaneous Hypertension and Prostate Hyperplasia
Bromodeoxyuridine cell culture Alamar Blue growth
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2008/12/19
Spontaneously hypertensive rats (SHRs), a commonly used model of genetic hypertension, exhibit features of glandular hyperplasia of the ventral prostate, including the narrowing of acini with epitheli...
Antisperm Autoantibody Response After Unilateral Vas Deferens Ligation in Rats: When Does it Develop?
Autoimmune response vasectomy testicular damage immunologic infertility
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2008/12/8
Unilateral obstruction or injury to the vas deferens can result in significant injury to the contralateral testicle. Antisperm autoantibodies are thought to play a significant role in this phenomeno...
Changes in Hormone Sensitivity in the Ventral Prostate of Aging Sprague-Dawley Rats
Lipofuscin antioxidants stroma age hormone-dependent regression apoptosis
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2008/12/3
The adult rat ventral prostate, which has been used extensively as a model for hormone-dependent prostate cancer, is composed of hormone-dependent columnar secretory epithelial cells and a mixture...
Differences in sperm motion between high- and low-shuttlebox avoidance rats (Hatano strains)
sperm motion high- and low-shuttlebox rats (Hatano strains)
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2008/12/2
Sperm from the caudal epididymis of 2 inbred strains of Sprague-Dawley (SD) rats, selected on the basis of their high- or low-shuttlebox avoidance responses, were analyzed for motion characteristics...
Postweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in rats
gossypol results epididymis-specific effects puberty adulthood rats
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2008/12/2
Gossypol, a yellow pigment found in cottonseeds, well known for its antifertility properties in animals, has been used as a contraceptive by men. The aims of this work were to evaluate the effects o...