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The ethane dimethanesulfonate-induced decrease in the fertilizing ability of cauda epididymal sperm is independent of the testis
Epididymis sperm maturation in utero insemination fertilization toxicant
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2009/2/12
Several decades ago it was reported that when adult male rats were exposed to a single injection of 50 mg/kg body weight ethane dimethanesulfonate (EDS) and mated with untreated females, average l...
Long-term alterations in the permeability of the blood-testis barrier following a single intratesticular injection of dilute aqueous glycerol
Blood-testis barrier permeability glycerol seminiferous tubules Sertoli cells
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2009/2/12
The mechanism whereby glycerol exerts its antispermatogenic action is not known. The objective of this study was to determine, with the use of [3H]inulin and [125I]albumin by in vivo and in vitro ...
Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse
Testis propylthiouracil Sertoli cells hypothyroidism
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2009/2/12
Male rats made hypothyroid during neonatal life show unprecedented increases in adult testis size and daily sperm production (DSP). To determine if this effect was unique to the rat or could also ...
Comparison of effects of 0.5 and 3.0 Gy X-irradiation on lipid peroxidation and antioxidant enzyme function in rat testis and liver
0.5 and 3.0 Gy X-irradiation lipid peroxidation antioxidant enzyme function rat testis
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2009/2/12
The prooxidant effect of X-irradiation on rat testis and liver tissue was studied with doses of 0.5 and 3.0 Gy; the latter dose kills the proliferating spermatogonia and causes a maturation-depletio...
Motile sperm in human testis biopsy specimens
Wet prep motility reproductive tract obstruction
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2009/2/12
We prospectively studied 62 consecutive infertile men who underwent 100 intraoperative wet prep cytological examinations of testis biopsy material obtained simultaneously with permanently fixed spec...
Pituitary adenylate cyclase activating polypeptide（PACAP）can cross the vascular component of the blood-testis barrier in the mouse
Influx constants transport peptide T vasoactive intestinal polypeptide
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2009/2/12
Pituitary adenylate cyclase activating polypeptide (PACAP), present in highest concentrations in the hypothalamus and testes, affects the release of LH, FSH, and prolactin, as well as Sertoli cell...
Immunocytochemical localization of the Yf subunit of glutathione S-transferase P shows regional variation in the staining of epithelial cells of the testis, efferent ducts, and epididymis of the male rat
Epididymis testis basal cells glutathione S-transferase detoxification
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2009/2/11
Glutathione S-transferases (GSTs) are a family of isozymes that catalyze the conjugation of glutathione (GSH), a tripeptide found in all mammalian cells; this function plays a protective role, as th...
Antioxidant enzyme activity in the maturing rat testis
Antioxidant enzyme activity maturing rat testis
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2009/2/11
Developmental profiles of the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), glutathione transferase (GSH-Tr), and hexose monophosphate ...
Human interleukin-1 alpha crosses the blood-testis barriers of the mouse
Cytokine Sertoli cell transport blood-brain barrier germinal cells
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2009/2/10
Interleukin-1 alpha (IL-1 alpha) has been shown to have direct effects on the gonads, affecting steroidal secretion, DNA synthesis by spermatogonia, and the immune function of the testes. It is un...
GnRH-A induced arrest of spermiogenesis in rats is associated with altered androgen binding protein distribution in the testis and epididymis
GnRH-antagonist Sertoli cell spermatogenesis
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2009/2/10
This study examines the effects of a potent gonadotropin releasing hormone (GnRH)-antagonist (GnRH-A, Ac-D[2] Nal1, 4-CL-D Phe2, D-Trp3, D-Arg6, D-Ala10) upon the distribution of androgen binding pr...
Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase（3 beta-HSD）in human testis as studied by immunocytochemistry
Ontogeny 3ı -hydroxysteroid dehydrogenase/iı -iS.” isomerase human testis immunocytochemistry
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2009/2/7
The enzyme complex 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) is involved in the biosynthesis of all classes of active steroids, including androgens. To correl...
Atrial natriuretic peptide precursor material in rat testis
ANP mRNA RF-HPLC northern blot hybridization
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2009/2/6
Atrial natriuretic peptide (ANP) has recently been suggested to play a role in the regulation of male reproduction. Specifically, it has been shown to affect steroidogenesis in Leydig cells. The dat...
Changing relationships between testis size, Sertoli cell number and spermatogenesis in Sprague-Dawley rats
reproduction testes gametogenesis correlations
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2009/2/6
Relationships between several reproductive characteristics were investigated in 25 Sprague-Dawley rats aged 60, 150, and 240 days (n = 75). Daily sperm production correlated with body weight (r = 0....
Spermatic cord torsion: effects of cyclosporine and prednisone on fertility and the contralateral testis in the rat
spermatic cord torsion immunosuppression testicular damage
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2009/2/6
Unilateral spermatic cord torsion results in contralateral degeneration and reduced fertility in the prepubertal male rat. This study was conducted to investigate the use of immunosuppression with c...
Does ethane 1,2-dimethanesulphonate（EDS）have a direct cytotoxic effect on the seminiferous epithelium of the rat testis?
spermatogenesis cytotoxic testosterone testes rat
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2009/2/6
The authors examined the possibility that ethane 1,2-dimethanesulphonate (EDS) has a cytotoxic effect on spermatogenesis that is not secondary to androgen withdrawal resulting from the well known cy...