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The biopsy of bone and soft tissue sarcoma is an integral part in the management of patients with these disorders and inadequate, inappropriate or inaccurate non-representative biopsies do lead to poo...
Principles of limb sparing surgery in bone and soft tissue sarcoma
limb sparing surgery in bone soft tissue sarcoma
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2015/4/1
The standard for local control of malignant bone and soft tissue tumours has been amputation. Advances in multimodality treatment have seen a shift towards preservation of the limb. Sophisticated tech...
The role of radiology in assessing bone and soft tissue sarcomas encompasses the initial detection and diagnosis of the lesion, staging the lesion both locally and systemically, guiding biopsy of the ...
Experimental and Computational Analysis of Dynamic Loading for Bone Formation
Biomechanics Mechanical Loading Bone Formation Resonance
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2015/1/12
Bone is a dynamic tissue that is constantly remodeling to repair damage and strengthen regions exposed to loads during everyday activities. However, certain conditions, including long-term unloading o...
Signaling Pathways Involved in Mechanical Stimulation and ECM Geometry in Bone Cells
Mechanical Stimulation Osteoblast ECM
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2015/1/12
The proliferation and differentiation of osteoblasts are influenced by mechanical and geometrical growth environments. A specific aim of my thesis was the elucidation of signaling pathways involved in...
Bone material properties and mineral matrix contributions to fracture risk or age in women and men
collagen osteoporosis
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2014/12/4
The strength of bone is related to its mass and geometry, but also to the physical properties of the tissue itself. Bone tissue is composed primarily of collagen and mineral, each of which changes wit...
Introduction – Bone turnover and fracture risk
osteoporosis bone turnover fracture remodeling
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2014/12/4
Introduction – Bone turnover and fracture risk.
Osteoporosis and fracture risk: bone matrix quality
remodeling bisphosphonates mineralization
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2014/12/4
Osteoporosis and fracture risk: bone matrix quality.
Identification of material parameters based on Mohr-Coulomb failure criterion for bisphosphonate treated canine vertebral cancellous bone
material parameter identification Mohr-Coulomb failure criterion trabecular bone
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2014/12/4
Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumpti...
Parathyroid Hormone Enhances Mechanically Induced Bone Formation, Possibly Involving L-Type Voltage- Sensitive Calcium Channels
parathyroid hormone bone formation
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2014/12/4
PTH and mechanical loading might act synergistically on bone formation. We tested the in vivo effect of the L-type voltage-sensitive calcium channel (VSCC) blocker, verapamil, on bone formation induce...
Exercise-Induced Changes in the Cortical Bone of Growing Mice Are Bone and Gender Specific
mechanical properties pQCT matrix changes
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2014/12/4
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to no...
Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body
trabecular bone cortical shell suppressed bone turnover
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2014/12/4
The relative biomechanical effects of antiresorptive treatment on cortical thickness vs. trabecular bone microarchitecture in the spine are not well understood. To address this, T-10 vertebral bodies ...
Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra
anti-remodeling bisphosphonates animal models
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2014/12/4
Introduction Bone turnover suppression in sites that already have a low surface-based remodeling rate may lead to oversuppression that could have negative effects on the biomechanical properties of bo...
A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover
trabecular bone bone strength suppressed bone turnover
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2014/12/4
This study addressed the effects of changes in trabecular microarchitecture induced by suppressed bone turnover—including changes to the remodeling space—on the trabecular bone strength–volume fractio...
Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following three years of daily treatment
Bisphosphonates remodeling suppression
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2014/12/4
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated with a wide range of bisphosphonate doses. Data regarding toughne...