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8-Br-cAMP 诱导人食管癌细胞凋亡的研究
细胞凋亡 82Br2cAMP Eca2109 细胞系
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2008/10/17
目的:本文主要研究人食管癌109 细胞株经8-Br-cAMP 诱导后细胞凋亡的发生。方法:用TUNEL 法观察诱导后细胞凋亡情况。结果:人食管癌109 例细胞株自发凋亡率为1013 %;经8-Br-cAMP 诱导后凋亡倾向细胞增加。结论:8-Br-cAMP具有促进人食管癌细胞凋亡倾向的效应。
摘要
目的:
探讨8-Br-cAMP对人肺腺癌细胞株A549细胞端粒酶活性和P53蛋白表达的影响。
方法:
用终浓度分别为20 μmol/L及60 μmol/L的8-Br-cAMP处理人肺腺癌细胞株A549细胞,以未处理者为空白对照。采用PCR-ELISA法检测端粒酶活性,用免疫荧光标记法测定P53蛋白的表达。
结果:
8-Br-cAMP作用后的A549细胞,端粒酶活性明显降低,P53...
钙调素拮抗剂对人肺癌细胞增殖抑制及与cAMP信号系统相关性之初探
钙调素 环腺苷酸 蛋白激酶A 三氟拉嗪(TFP)
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2007/12/17
摘要 对钙调素(CaM)拮抗剂—三氟拉嗪(trifluoperazine,TFP)在人肺癌细胞PLA801的增殖抑制中的作用和CaM与cAMP信号系统水平的变化进行了研究.用5、10、15和20μmol/LTFP处理人肺癌细胞时观察到TFP在抑制细胞内CaM活性的同时,抑制了细胞的增殖.药物处理的细胞在软琼脂中形成的集落数减少且明显小于对照组细胞.使用流式细胞光度术分析细胞周期的结果表明:10μm...
cAMP介导内皮素-1对大鼠黄体细胞孕酮分泌的作用
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2007/7/28
期刊信息
篇名
cAMP介导内皮素-1对大鼠黄体细胞孕酮分泌的作用
语种
中文
撰写或编译
作者
徐斯凡
第一作者单位
刊物名称
生殖医学杂志
页面
1995,4(2),88
出版日期
1995年
月
日
文章标识(ISSN)
相关项目
内皮素在卵巢内分布、对卵巢和睾丸的作用及其机理研究
吗啡长时程作用对新生鼠TM神经细胞cAMP和cGMP的影响以及青藤碱的干预作用
<
2007/7/25
药物依赖是一种反复发作的脑疾病。国内外围绕药物依赖的神经生物学研究已从整体行为,深入到神经核、神经通路、细胞、分子及基因水平。一般认为,吗啡依赖主要与内阿片肽能神经系统有关,但内阿片肽系统的变化并不能完全解释吗啡成瘾的全部机理。近二十多年的研究表明,在药物耐受、依赖与戒断过程中,几乎所有的神经系统及神经递质都发生了变化。如中枢单胺神经系统在吗啡依赖中发挥的作用,单胺类神经递质与吗啡依赖的密切关系,...
慢性心力衰竭患者血浆肾上腺髓质素和cAMP含量的变化及相互关系
肾上腺髓质素 心力衰竭
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2007/7/25
近20年来人们已初步认识到慢性心力衰竭(CHF)的进展恶化是由于血液动力学和神经内分泌变化相互作用的结果,而神经内分泌激素及细胞因子的激活已成为近代心力衰竭的主要理论。目前研究发现肽类信号系统与心力衰竭的发展密切相关,其中肾上腺髓质素(adrenomedullin, ADM)在心衰过程中的代偿作用已得到国内外学者的共识,基础研究证实其可通过激活cAMP-PKA等信号传导系统而实现有益的生物学效应[...
A Diabetes Camp as the Service-Learning Capstone Experience in a Diabetes Concentration
service-learning diabetes camp advanced pharmacy practice experience
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2018/5/2
Objectives. To assess the effectiveness of a service-learning advanced pharmacy practice experience (APPE) in a diabetes camp to improve student confidence in diabetes knowledge and related skills
De...
UVULECTOMY AND OTHER TRADITIONAL HEALING PRACTICES: TRADITIONAL HEALERS‘ PERCEPTIONS AND PRACTICES IN A CONGOLESE REFUGEE CAMP IN TANZANIA
traditional healing healers uvulectomy
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2010/12/10
Little is studied about traditional healers‘ perceptions toward and practice of uvulectomy, which is known as a traditional surgical practice mainly in Africa and which sometimes results in severe com...
Phosphodiesterase 4 cAMP phosphodiesterases as targets for novel anti-inflammatory therapeutics
A-kinase anchoring protein (AKAP) β-arrestin phosphodiesterase 4 phosphodiesterase inhibitors Src tyrosine kinase
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2010/11/22
Cyclic nucleotides are powerful signaling molecules and their sole means of removal is through the action of cyclic nucleotide phosphodiesterases (PDEs). Elevating levels of cAMP is beneficial in many...
Service-Learning at a Camp for Children With Asthma as Part of an Advanced Pharmacy Practice Experience
service-learning advanced pharmacy practice experience asthma camp pediatric
<
2018/4/3
Objectives. To describe a service-learning opportunity within an advanced pharmacy practice experience and report satisfaction survey results from 2001 through present.
Design. Pharmacy students volu...
Diabetes Camp As An Experiential Clerkship Site
camp diabetes clerkship pediatric advanced practice experience
<
2018/3/19
Objective. This paper describes the incorporation of a diabetes camp into the experiential pharmacy education program at the Texas Tech University School of Pharmacy.
Methods. Students on the clerksh...
观察了MFA对离体豚鼠气管张力,cAMP的影响及二者的关系。发现:MPA(0.03~0.6mmol·L-1)剂量依赖性抑制KCI,ACh及Hist所致的气管条收缩,同时伴有cAMP升高,两者间有良好的相关性(r值分别为0.753,0.9112和0.9567,P<0.001);MFA(0.03mmol·L-1)能够增强Ami和Iso的气管平滑肌舒张作用,后者同时伴有cAMP升高。提示:MFA对支气管...
6-(αα-二苯基乙酰哌嗪基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮对兔血小板聚集及TXB2,cAMP的影响
6-(αα-二苯基乙酰哌嗪基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮
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2010/3/1
6-(αα-二苯基乙酰哌嗪基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮(简称DMDP)是我院新合成的哒嗪酮的衍生物。DMDP可以显著抑制由花生四烯酸(AA(?),ADP和血小板活化因子(PAF)诱导的免血小板聚集,其IC50分别为1.12±0.1.4.19±0.5和2.97±0.1μmol/L。实验还表明DMDP在1~500 μmol/L浓度范围内呈剂量依赖性地抑制兔血小板内血栓素B2含量...
Astragalus saponin 1, one of the components isolated from Astragalus membranaceus Bge was found to induce accumulation of cAMP in rabbit plasma at the ip dose of 10mg/kg. The increase of cAMP started ...
By using protein binding assay for cAMP it was shown that, in contrast to the spleen of the inbred 615 mice; very low cAMP contents in the spleen of mice bearing leukemia L615 were observed. At the do...