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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
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2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019
coronavirus disease-19 (COVID-19) RNAemia IL-6 critically ill patients cytokine storm
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2020/6/12
Although the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in respiratory specimens has been widely used to diagnose coronavirus disease 2019 (COVID-19), it is u...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
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2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Structure Mpro SARS-CoV-2 discovery inhibitors
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2020/6/12
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (...
Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay
SARS-CoV-2 RT-LAMP COVID-19 Detection Visual
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2020/6/12
To evaluate a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and compare it with RT-PCR.
Effectiveness of convalescent plasma therapy in severe COVID-19 patients
COVID-19 convalescent plasma treatment outcome pilot project
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2020/6/12
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospect...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
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2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
Hydroxychloroquine less toxic derivative chloroquine effective inhibiting SARS-CoV-2 infection vitro
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2020/6/12
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local econom...
探讨抗菌洗手液在新型冠状病毒肺炎战疫一线防护中对复用护目镜的防雾应用及效果。方法 在穿戴防护装备时,先将反复消毒后的护目镜用抗菌洗手液内外擦拭,待干后戴上。采用问卷调查方式对使用者进行认可度调查。
15例COVID-19患者治疗后痰，粪便标本新型冠状病毒核酸检测结果比较
新型冠状病毒肺炎 新型冠状病毒 痰 粪便 标本 核酸检测 COVID-19 SARS冠状病毒-2-
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2021/2/26
探讨粪便样本作为疑似或确诊新型冠状病毒肺炎（COVID-19）患者筛查的可行性。方法利用实时RT-PCR技术，对15例COVID-19患者治疗后痰，粪便标本中新型冠状病毒的ORF1ab，N基因以及人体细胞管家基因核糖核酸酶P（核糖核酸酶P，RNase P）进行检测，比较痰，粪便标本检测阳性情况。
应对新型冠状病毒肺炎防护服的选择和使用
防护服 防护用品 新型冠状病毒肺炎 感染防控 标准 COVID-19 2019-nCoV SARS-COV-2
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2021/2/26
防护服是医务人员抗击传染病疫情中非常重要的个人防护用品，特别是在应对传播途径未知的新发传染病，以及传播风险很高的传染病中。分泌物，喷溅物，颗粒物等接触人体，保护医务人员健康，是战胜新冠肺炎疫情的重要防护用品。标准和医用防护服的应用范围和评价指标，以期为医务人员选择符合要求的防护服提供帮助
预见性护理措施在经皮微创胸腔置管闭式引流术后结核性渗出性胸膜炎患者中的应用
结核性渗出性胸膜炎 皮微创胸腔置管闭式引流 预见性护理 并发症 预防
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2020/12/28
研究预见性护理措施在经皮微创胸腔置管闭式引流术后结核性渗出性胸膜炎患者中的应用效果。方法 选择2016年6月至2018年6月在安康市中心医院传染科诊治的结核性渗出性胸膜炎患者90例进行研究，按照随机数表法分为观察组和对照组，每组45例。所有患者均经皮微创胸腔置管闭式引流术治疗，对照组采用常规护理措施，观察组采用预见性护理措施。比较两组患者的住院时间、胸水吸收时间、血沉恢复正常时间、护理前后的生活质...
2020年1月，热带病防控关键技术研究团队以热带转化医学教育部重点实验室为第一单位在JCR 1区期刊《Sensors and Acuators B: Chemical》（影响因子6.393）上以article形式发表了关于CALP检测的最新研究成果，论文题为：An enzyme-free ultrasensitive electrochemical immunosensor for c...
An outbreak of unusual respiratory disease, initially dominated by pneumonia, in Wuhan, China, is caused by infection by a novel coronavirus.The new virus was initially named 2019-nCoV by WHO.1–3
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
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2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...