搜索结果: 16-30 共查到“国际动态 肿瘤学”相关记录142条 . 查询时间(2.776 秒)
Exploring the links between diet and cancer（图）
饮食 癌症 胃肠道癌症 肠道干细胞
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2023/6/5
Every three to five days, all of the cells lining the human intestine are replaced. That constant replenishment of cells helps the intestinal lining withstand the damage caused by food passing through...
The Basser Center for BRCA at Penn Medicine is the first comprehensive center for the research, treatment, and prevention of BRCA-related cancers.
In what may turn out to be a long-missing piece in the puzzle of breast cancer, Harvard Medical School researchers have identified the molecular sparkplug that ignites cases of the disease currently u...
科学家在癌症如何逃避免疫系统方面取得新进展
癌症 免疫系统 转移的
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2024/1/16
近日，发表在《Nature Communications》上的一项新研究中，来自新加坡国立癌症中心、杜克-新加坡国立大学医学院等多家学术机构的联合研究团队发现了癌症如何逃避免疫系统后在体内转移的机制，并探索了抑制这一危险机制的可能性。该研究对开发癌症治疗的新策略具有重要意义。
Nanoparticles provoke immune response against tumors but avoid side effects（图）
纳米颗粒 肿瘤 免疫反应
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2023/6/6
Cancer drugs that stimulate the body’s immune system to attack tumors are a promising way to treat many types of cancer. However, some of these drugs produce too much systemic inflammation when delive...
A novel cancer therapeutic, combining antibody fragments with molecularly engineered nanoparticles, permanently eradicated gastric cancer in treated mice, a multi-institutional team of researchers fou...
A new control switch could make RNA therapies easier to program（图）
控制开关 RNA疗法 编程 治疗性RNA分子 癌细胞
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2023/6/21
Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other disease...
科学家成功开发出靶向STAT5的小分子化合物
靶向STAT5 小分子化合物 信号转导 转录激活因子
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2024/1/17
信号转导和转录激活因子5（STAT5）在某些血液系统恶性肿瘤的发生和进展中起着关键作用，如慢性粒细胞白血病（CML），因而一直以来是一个有吸引力的治疗靶标，但成功靶向STAT5是困难的。近期，密歇根大学的科学家开发了一种选择性小分子降解剂——AK-2292，它可以成功靶向并且去除体内的STAT5蛋白。研究成果发表在《Nature Chemical Biology》期刊，标题为“A selectiv...
科学家揭示抗肿瘤免疫反应与生物昼夜节律关系
抗肿瘤 免疫反应 生物昼夜节律
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2024/1/18
恶性肿瘤是全球主要的公共卫生问题，近年来，由于饮食、环境、人口的老龄化等因素，全球恶性肿瘤发病率不断增长，恶性肿瘤作为主要死因的情况日益突出。越来越多研究发现，昼夜节律因子在肿瘤的发生发展中起重要调控作用。然而，作为肿瘤治疗的热门靶点，肿瘤免疫系统是否受昼夜节律的调控，目前并不清楚。
科学家绘制肺肿瘤免疫微环境的单细胞空间图谱
肺肿瘤 免疫微环境 单细胞 空间图谱
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2024/1/18
目前，大多数临床策略仍依赖于肿瘤亚型的组织病理学分层，而对这些分层亚型中单细胞表型的空间位置信息知之甚少。加拿大麦吉尔大学研究团队绘制了肺肿瘤免疫微环境的单细胞空间图谱。该研究成果于近日发表在《Nature》杂志上，题为：Single-cell spatial landscapes of the lung tumour immune microenvironment。
科学家揭示原癌基因Cyclin E在肿瘤全基因组倍增中的重要作用
原癌基因 Cyclin E 肿瘤全基因组倍增
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2024/1/18
人体绝大多数细胞为二倍体，同时，机体存在大量细胞周期调控机制以确保细胞在连续的分裂过程中保持二倍体状态。全基因组倍增（Whole Genome Duplication, WGD）是具有组织特异性的常见基因突变模式，即天然二倍体细胞转变为基因不稳定的四倍体细胞。WGD在肿瘤的发生与进展过程中发挥重要驱动作用，且通常与患者预后不良有关，但WGD发生的细胞及分子机制尚不清楚。
In many instances, the physical manifestation of cancers and the ways they are subsequently diagnosed is via a tumor, tissue masses of mutated cells and structures that grow excessively. One of the ma...
Immunotherapy — drug treatment that stimulates the immune system to attack tumors — works well against some types of cancer, but it has shown mixed success against lung cancer.
New Cornell research is providing a fresh view into the ways a common chemotherapy agent, etoposide, stalls and poisons the essential enzymes that allow cancer cells to flourish.
Treating cancer with combinations of drugs can be more effective than using a single drug. However, figuring out the optimal combination of drugs, and making sure that all of the drugs reach the right...