搜索结果: 61-75 共查到“国际动态 生物工程”相关记录1281条 . 查询时间(5.645 秒)
科学家提出APOE4通过胆固醇失调损害少突胶质细胞的髓鞘形成
APOE4 胆固醇失调 少突胶质细胞 髓鞘形成
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2024/1/23
载脂蛋白E4（以下简称“APOE4”）是阿尔茨海默病关联性最强的遗传风险因素。但APOE4表达水平及功能对人脑的影响尚不明确，这限制了对携带APOE4阿尔茨海默病风险因素个体开发靶向治疗的方向。美国麻省理工学院等研究团队发现，APOE4通过少突胶质细胞中胆固醇失调从而损害髓鞘。该研究成果以题为“APOE4 impairs myelination via cholesterol dysregulat...
科学家首次发现促进肌动蛋白成熟的蛋白酶
肌动蛋白 成熟 蛋白酶
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2024/1/23
肌动蛋白参与肌肉收缩、细胞分裂和细胞运动等重要生理过程，但是肌动蛋白如何从非活性的前体被加工成为活性状态尚待揭示。荷兰癌症研究所的科研人员发现了一种调控肌动蛋白成熟的蛋白酶。相关成果在《Science》发表，论文的标题为：Actin maturation requires the ACTMAP/C19orf54 protease。
New CRISPR-based tool inserts large DNA sequences at desired sites in cells（图）
CRISPR 新型工具 大DNA序列 PAST 基因工程
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2023/6/21
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.
Alzheimer’s risk gene undermines insulation of brain’s “wiring”（图）
阿尔茨海默氏症 风险基因 APOE4 脑细胞 隔离神经元
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2023/6/21
It’s well-known that carrying one copy of the APOE4 gene variant increases one’s risk for Alzheimer’s disease threefold and two copies about tenfold, but the fundamental reasons why, and what can be d...
A team of scientists at the Whitehead Institute for Biomedical Research and the Broad Institute of MIT and Harvard has systematically evaluated the functions of over 5,000 essential human genes using ...
The liver’s ability to regenerate itself is legendary. Even if more than 70 percent of the organ is removed, the remaining tissue can regrow an entire new liver.
In recent years, scientists who study gene expression in cells have used a method that essentially pins a tail on RNA and tracks their whereabouts. However, certain types of RNA evade the process. Now...
Illumina首个中国生产制造基地在沪启用，总投超5亿（图）
基因测序 因美纳 医学检测
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2023/3/30
据闵行区经委消息，全球基因测序技术领军企业因美纳，近日在沪启用在华首个生产制造基地，并计划未来5年逐步实现高端基因测序仪及耗材全面本土化生产。
About 70 percent of all human proteins include at least one sequence consisting of a single amino acid repeated many times, with a few other amino acids sprinkled in. These “low-complexity regions” ar...
Within a given tissue or organ, cells may appear very similar or even identical. But at the molecular level, these cells can have small differences that lead to wide variations in their functions.
东南大学科研团队在《Nature Communications》上发表最新成果（图）
胚胎干细胞 DNA复制 R-loop
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2022/9/16
近日，东南大学生命科学与技术学院林承棋教授和罗卓娟教授团队在国际著名期刊《Nature Communications》发表了题为“ZFP281-BRCA2 prevents R-loop accumulation during DNA replication”的研究论文，报导了ZFP281与BRCA2互作阻碍R-loop异常积累，维持胚胎干细胞DNA复制的正常进程。
Cells in complex organisms undergo frequent changes, and researchers have struggled to monitor these changes and create a comprehensive profile for living cells and tissues. Historically researchers h...
A newly identified stem cell regulator enables lifelong sperm production（图）
干细胞调节器 干细胞更新因子 细胞工程
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2023/7/10
Unlike women, who are born with all the eggs they’ll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, ...
研究人员研发出世界上最小的生物力学连接装置
微小氨基酸链 生物力学 缩氨酸 基因工程
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2022/6/16
普林斯顿大学的研究人员制造出世界上最小的机械互锁生物结构，一个由称为肽的微小氨基酸链组成的双环链。该研究结果发表于《自然·化学》（Nature Chemistry）上。
The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including MIT's Whitehea...