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An aspartic protease 47 causes quantitative recessive resistance to rice black-streaked dwarf virus disease and southern rice black-streaked dwarf virus disease
aspartic proteinase quantitative trait loci resistance variety RBSDV SRBSDV
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2023/4/21
Rice black-streaked dwarf virus disease (RBSDVD) and southern rice black-streaked dwarf virus disease (SRBSDVD) are the most destructive viral diseases in rice. Progress is limited in breeding due to ...
Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
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2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
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2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Performance Responses, Nutrient Digestibility, Blood Characteristics, and Measures of Gastrointestinal Health in Weanling Pigs Fed Protease Enzyme
Enzyme Growth Performance Nutrient Digestibility Protease Weanling Pig
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2016/7/27
Although exogenous protease enzymes have been used in poultry diets quite extensively, this has not been the case for pig diets. In general, due to their better gut fermentative capacity and longer tr...
Detergent Potential of a Spoilage Protease Enzyme Liberated by a Psychrotrophic Spore Former Isolated from Sterilized Skim Milk
Spoilage Protease Enzyme Sterilized Skim Milk
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2016/6/1
The organism isolated from sterilized skim milk was identified as Bacillus cereus. B. cereus was found to be capable of producing protease enzyme at an alkaline pH-10. To assess the possibility of exp...
GFP Variants with Alternative β‑Strands and Their Application as Light-driven Protease Sensors:A Tale of Two Tails
Green Fluorescent Proteins Peptide Hydrolases Light
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2016/5/25
Green fluorescent protein (GFP) variants that carry one extra strand 10 (s10) were created and characterized, and their possible applications were explored. These proteins can fold with either one or ...
Allosteric Regulation of Dengue Virus Type 2 Protease
Dengue Virus Structure of NS2B-NS3pro
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2014/11/20
Dengue Fever is a global problem with a worldwide effectiveness that put 2.5 Billion people under the risk, infect 50 million people and causes 30000-50000 people death each year. DHF was first recogn...
Isolation and Characterization of Thermotolerant Alkaline Serine Protease of Bacillus sp. P-02
Thermotolerant Alkaline Isolation and Characterization
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2016/6/2
Twelve bacterial strains isolated from the soils sample were screened for protease production on skimmed milk agar. Among them, strain P-02 was adjudged as the best protease producer and was identifie...
PROTEASE INHIBITOR FROM THE CRUDE EXTRACT OF PLANT SEEDS AFFECTS THE DIGESTIVE PROTEASES
Lathyrus sativus Vicia faba Prosopis farcta Panicum miliaceum fall web worm protease inhibitors trypsin inhibitor
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2014/2/21
Proteases are one of the most important digestive enzymes in the midgut of Hyphantria cunea Drury. Proteases are responsible for protein digestion. In the present study, we evaluated the efficiency of...
Purification and Properties of a Collagenolytic Protease Produced by Bacillus cereus MBL13 Strain
Bacillus cereus MBL13 collagenolytic protease type I collagen metalloprotease
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2010/10/14
A novel collagenase-producing bacterium has been isolated and identified as Bacillus
cereus MBL13. From the culture supernatant of B. cereus MBL13 grown on bone collagen as
the sole carbon and nitro...
Long-term Downregulation of Protease-activated receptor-2 Expression in Distal Colon in Rats Following Bacillary Dysentery. Regulatory Peptides
PAR-2 Colonic smooth muscle Motility disorder
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2014/5/16
The aim of this study was to determine changes of PAR-2 expression in distal colon and the sensitivity of colonic muscle to SLIGRL-NH2, the PAR-2-activating peptide (PAR-2-AP) following bacillary dyse...
Protease-activated receptor-2 (PAR-2) regulates enterotoxigenic Escherichia coli-induced diarrhea during weaning in piglets
Diarrhea weaning piglet gastrointestinal tract
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2011/1/11
Protease-activated receptor-2 (PAR-2) is a member of the G-protein-coupled receptor family. The proteases that activate PAR-2 are released during inflammation and injury, with PAR-2 regulating the res...
Effects of Protease-resistant Antimicrobial Substances Produced by Lactic Acid Bacteria on Rumen Methanogenesis
Methane Production Lactic Acid Bacteria In vitro Fermentation
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2016/5/4
Effects of protease-resistant antimicrobial substances (PRA) produced by Lactobacillus plantarum and Leuconostoc citreum on rumen methanogenesis were examined using the in vitro continuous methane qua...
The Enzymatic Activity and Molecular Characterization of a Secreted Subtilisin-Like Protease in Microsporum gypseum and Trichophyton vanbreuseghemii
Keratinases Subtilisin-like protease Trichophyton vanbreuseghemii Microsporum gypseum
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2009/12/14
Background: Subtilisin -like proteases are the group of proteases including keratinases found in dermatophytes which degraded keratin. Determination of the proteases activity of Trichophyton vanb...
Oral candidiasis in HIV+ patients under treatment with protease inhibitors
HIV Candida albicans Protease inhibitors
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2009/10/16
The purpose of this work was to evaluate the influence of Protease Inhibitors (PI) on the occurrence of oral candidiasis in 111 HIV+ patients under PI therapy (Group A). The controls consisted of 56 p...