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共聚焦激光显微内镜在体评估NSAIDs相关胃病及其药物干预效果
黏膜屏障功能障碍 替普瑞酮 雷贝拉唑
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2014/9/26
应用共聚焦激光显微内镜（CLE）在体评价非甾体抗炎药（NSAIDs）相关胃病中黏膜屏障功能障碍，探索替普瑞酮和雷贝拉唑对急性胃黏膜损伤预防与治疗的作用机制。方法 建立CLE急性胃黏膜损伤评分系统，在体评价NSAIDs相关急性胃黏膜损伤及药物干预效果，测定胃黏膜中occludin及ZO-1的表达水平。结果 NSAIDs相关胃病模型组黏膜损伤评分明显高于正常组，ZO-1与occludin表达明显减少。...
Determination of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Milk and Fresh Cheese Based on the Inhibition of Cyclooxygenase
food analysis COX inhibition biosensor
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2009/8/10
A biosensor for rapid determination of nonsteroidal anti-inflammatory drugs (NSAIDs) is described based on the inhibition of cyclooxygenase enzyme (both isoforms) by NSAIDs. The results show the full ...
NSAIDs相关性胃肠病
NSAIDs 胃肠病
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2009/7/30
长期以来, 非甾体类抗炎药(nonsteroidal anti-inflam-matory drugs, NSAIDs)被广泛应用于治疗各种风湿性疾病及心脑血管疾病, 但由于其可引起多系统并发症, 尤其是胃肠黏膜损伤作用, 即NSAIDs相关性胃肠病, 表现为消化吸收功能不良、腹胀、腹痛、溃疡、出血、穿孔、贫血、低蛋白血症等, 而限制了其进一步广泛使用; NSAIDs相关性胃肠病发病机制主要有环氧...
NSAIDs预防肿瘤的病例对照及实验研究
肿瘤 病例 对照
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2008/12/15
NSAIDs是临床上常用的抗炎镇痛药，近年来的研究表明，这一类药有一定的抗肿瘤作用。本研究通过病例对照分析流行病学研究、动物实验、及体外细胞培养的方法证实，NSAIDs对结肠癌、直肠癌、肠息肉有明显的保护作用，OR值分别为0。15（95%CI0.11-0.58）、0.13（95%CI0.05-0.35）、0.212（95%CI0.07-0.65），其中阿司匹林在临床上最常用，单独LOGIST...
Endoscopic findings in children on non-steroidal anti-inflammatory drugs (NSAIDs)
Endoscopic findings Children Non-steroidal anti-inflammatory drugs
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2015/9/9
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) remain as the initial approach to the pharmacologic management in juvenile rheumatoid arthritis (JRA). Gastrointestinal (GI) damage associate...
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications
Derivatives Synthesis Spectroscopic Characterization Biological Applications
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2010/4/20
Some new di- and tri-organotin(IV) derivatives of 4 different non-steroidal anti-inflammatory drugs (NSAIDs) with the general formulae R2SnL2 and R3SnL (where R = n-C8H17 and C6H5CH2) and L = 2-[(2,3-...