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The duration of the cycle of the seminiferous epithelium is altered by administration of 2,5-hexanedione in the adult Sprague-Dawley rat
seminiferous epithelium 2,5-hexanedione adult Sprague-Dawley rat
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2009/2/13
The duration of the cycle of the seminiferous epithelium is believed to be under genetic control rather than being influenced by other factors. However, the frequencies of certain spermatogenic stag...
2,5-hexanedione exposure in the rat results in long-term testicular atrophy despite the presence of residual spermatogonia
Germ cell repopulation Sertoli cell toxicity spermatogonia
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2009/2/7
Charles River CD rats (approximate weight, 208 g) were exposed to 1.0% 2,5-hexanedione (2,5-HD) in drinking water for 5 weeks. Rats were killed 27, 60, and 75 weeks after exposure to evaluate the re...
Experimental cryptorchidism protects against long-term 2,5-hexanedione-induced testicular germ cell loss in the rat
cryptorchidism experimental cryptorchidism
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2009/2/6
Male infertility is a common side effect of aggressive cancer chemotherapy. One possible approach to decreasing gonadal injury in this setting is the production of artificial cryptorchidism (elevati...