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Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fertilizing capacity, and may reflect other abnormalities of spermiogenesis
Semen sperm chromatin fertilization IVF infertility
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2008/12/29
During the spermatid elongation stage of spermiogenesis approximately 85% of sperm nuclear histones are replaced by protamines. Protamines increase the packing ratio of sperm chromatin, presumably fac...
Protamine Levels Vary Between Individual Sperm Cells of Infertile Human Males and Correlate With Viability and DNA Integrity
Spermatogenesis male fertility
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2008/12/24
Sperm protamine deficiency has been associated with human male infertility. However, most studies have adopted a global approach to assessing sperm protamine levels. Thus, it is not known whether...
Sperm Nuclear Histone to Protamine Ratio in Fertile and Infertile Men：Evidence of Heterogeneous Subpopulations of Spermatozoa in the Ejaculate
Sperm DNA male infertility
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2008/12/24
Sperm protamine deficiency is observed in a subset of infertile men, suggesting that the relative histone to protamine ratio may be altered in the spermatozoa of these men. We measured the ratio of ...
DNA Integrity Is Compromised in Protamine-Deficient Human Sperm
Chromatin DFI DNA damage
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2008/12/23
The objective of this study was to examine the relationship between DNA integrity and protamines in human sperm. One hundred forty-nine male infertility patients were included in an Institutional Re...
Marked Differences in Protamine Content and P1/P2 Ratios in Sperm Cells From Percoll Fractions Between Patients and Controls
Chromatin condensation male infertility Percoll gradients sperm chromatin sperm morphology sperm motility
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2008/12/19
The various sperm cell types present in a simple ejaculate differ in their motility and morphology. However, little is known about the nuclear maturity of these sperm cells and their relationship wi...