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上调miR-181a抑制香烟提取物诱导的支气管上皮细胞致炎因子生成与collagen IV、fibronectin和α-SMA表达
微小RNA-181a 慢性阻塞性肺疾病 气道炎症 气道重塑 NF-κB/TGF-β1/Smad3信号通路
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2020/9/11
探讨微小RNA-181a（miR-181a）对香烟提取物（cigarette smoke extract，CSE）诱导的人支气管上皮细胞（human bronchial epithelial cells， HBECs）致炎因子生成与IV型胶原蛋白（collagen IV）、纤连蛋白（fibronectin）和α-平滑肌肌动蛋白（α-SMA）表达的影响，并分析其可能的机制。方法：RT-qPCR检测C...
Undenatured type II collagen (UC-II®) for joint support:a randomized,double-blind,placebo-controlled study in healthy volunteers
UC-II Undenatured type II collagen Joint function Knee extension Stepmill Joint pain
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2015/7/28
UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint disc...
Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
Atomic force microscopy Raman spectroscopy Reference point indentation MicroCT crystallinity modulus
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2015/1/12
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the...
Effects of Collagen Gel Stiffness on Cdc42 Activities of Endothelial Colony Forming Cells during Early Vacuole Formation
ECFC Vacuole Cdc42 Stiffness FRET
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2015/1/12
Recent preclinical reports have provided evidence that endothelial colony forming cells (ECFCs), a subset of endothelial progenitor cells, significantly improve vessel formation, largely due to their ...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague–Dawley Atomic Force Microscopy Raman Spectroscopy
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2014/12/4
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Distribution of Type I Collagen Morphologies in Bone: Relation to Estrogen Depletion
AFM Ultrastructure disease diagnosis
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2014/11/6
Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the u...
Type I Collagen Exists as a Distribution of Nanoscale Morphologies in Teeth, Bones and Tendons
collagen nanoscale morphologies bones
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2014/11/6
This study demonstrates that collagen, the most abundant protein in animals, exists as a distribution of nanoscale morphologies in teeth, bones, and tendons. This fundamental characteristic of Type I ...
Nanoscale Morphology of Type I Collagen is Altered in the Brtl Mouse Model of Osteogenesis Imperfecta
AFM nanoscale
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2014/11/6
Bone has a complex hierarchical structure that has evolved to serve structural and metabolic roles in the body. Due to the complexity of bone structure and the number of diseases which affect the ultr...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
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2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Nanoscale Structure of Type I Collagen Fibrils: Quantitative Measurement of D-spacing
Collagen fibril D-spacing 2D FFT AFM
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2014/11/6
This article details a quantitative method to measure the D-periodic spacing of type I collagen fibrils using atomic force microscopy coupled with analysis using a two-dimensional fast fourier transfo...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
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2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Urinary type IV collagen excretion predicts an increased urinary albumin-to-creatinine ratio in normoalbuminuric patients with diabetes
Type IV Collagen Diabetic Nephropathy Oxidative Stress Monocyte Chemoattractant Protein-1
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2013/1/30
Aims: We evaluated whether urinary excretion of type IV collagen (U-COL) may predict an increase in the urinary albumin-to-creatinine ratio (ACR) and what factors regulate U-COL in 145 normoalbuminuri...
Effects of kirenol on bovine type II collagen-induced rat lymphocytes in vivo and in vitro
奇壬醇 II型胶原 淋巴细胞 类风湿性关节炎
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2012/4/24
目的观察奇壬醇对牛II 型胶原特异性淋巴细胞体内和体外的免疫调节作用，探讨奇壬醇对抗原特异性淋巴细胞的免疫抑制作用机制。方法将Wistar 大鼠随机分为对照组、模型组、奇壬醇组和泼尼松龙组。除对照组外，均复制胶原诱导关节炎大鼠模型，造模当天开始给药。造模30 d 后取脾脏和引流淋巴结，制备单细胞悬液，经体外培养48 h 后，ELISA法检测培养上清中干扰素-γ（IFN-γ）、白介素-10（IL-1...
Creation of highly functional CO3Ap-collagen scaffold biomaterials
Scaffold biomaterials CO3Ap-collagen High function
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2010/11/26
Physicochemical properties of apatites are affected dramatically by the substitution of trace elements. Especially, biological apatites constituting bone and teeth contain several wt% of CO32– ions, w...
The instantaneous deformation of cartilage: effects of collagen fiber orientation and osmotic stress
cartilage collagen fiber orientation osmotic stress
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2010/1/7
The instantaneous deformation of cartilage: effects of collagen fiber orientation and osmotic stress.