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Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts
signaling Tyrosine kinase Osteoclasts
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2014/11/6
Bone loss is caused by the dysregulated activity of osteoclasts which degrade the extracellular bone matrix. The tyrosine kinase Pyk2 is highly expressed in osteoclasts, and mice lacking Pyk2 exhibit ...
Nmp4/CIZ suppresses the response of bone to anabolic parathyroid hormone by regulating both osteoblasts and osteoclasts
c-fos Fra-2 osteoclastogenesis
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2014/11/6
How parathyroid hormone (PTH) increases bone mass is unclear, but understanding this phenomenon is significant to the improvement of osteoporosis therapy. Nmp4/CIZ is a nucleocytoplasmic shuttling tra...
Signaling via the Pyk2-Src-Cbl complex downstream of integrins contributes to the assembly, organization, and dynamics of podosomes, which are the transient adhesion complexes of highly motile cells s...
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice
podosome organization bone density osteoclast functions
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2014/11/6
The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast ...
The Function of Bone As A Calcium Reservoir With A Consideration of the Cellular Pictures Seen in Resorption With Particular Reference to the Significance of Osteoclasts
Bone Calcium Reservoir Cellular Pictures Seen
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2009/3/19
The Function of Bone As A Calcium Reservoir With A Consideration of the Cellular Pictures Seen in Resorption With Particular Reference to the Significance of Osteoclasts.
Effect of appliance reactivation after decay of initial activation on osteoclasts, tooth movement, and root resorption
Orthodontic tooth movement Osteoclasts Histomorphometry Alveolar bone Root resorption
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2009/1/7
Clinical orthodontists frequently reactivate appliances following decay. Studies of tooth movement and tissue responses following reactivations indicate that linear tooth movement and rapid recruitm...
Evening Primrose Oil Effects on Osteoclasts during Tooth Movement
Evening primrose oil Osteoclast
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2008/11/27
This study was conducted to investigate the influence of supplemented evening primrose oil (EPO) on osteoclast expression during experimental tooth movement in rats. Forty-eight 10-week-old male S...
Root resorption of human deciduous teeth with apical periodontitis by cultured osteoclasts
Apical periodontitis Cultured osteoclasts Human deciduous teeth Root resorption Tartrate-resistant acidphosphatase (TRAP)
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2008/4/16
Roots of human deciduous teeth with apical periodontitis frequently show abnormal resorption as well as cementum deposition, and features that are different from those of physiological root resorption...
Expression and Function of Transmembrane-4 Superfamily (Tetraspanin) Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis
cell fusion NET-6 osteoclast tetraspanin Tspan-5
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2010/11/18
These data indicate that a diversity of tetraspanins is expressed in osteoclast precursors, and that cell fusion during osteoclastogenesis is regulated by cooperation of distinct tetraspanin family pr...