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Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
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2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis
Tdrd12 Tudor Spermatogenesis Acrosome Spermatid Testis
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2016/7/27
Tdrd12 is one of tudor domain containing (Tdrd) family members. However, the expression pattern of Tdrd12 has not been well studied. To compare the expression levels of Tdrd12 in various tissues, real...
A New View of Brain Development:Scientists Uncover Striking Differences Between the Adult and Newborn Mouse Brain
Brain Development Scientists Striking Differences Adult Newborn Mouse Brain
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2016/7/4
Columbia scientists have found that spikes in the activity of neurons in young mice do not spur corresponding boosts in blood flow — a discovery that stands in stark contrast to the adult mouse brain....
Disruptions to embryonic reprogramming alter adult mouse behavior
embryonic reprogramming adult mouse
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2016/2/22
Right after fertilization, embryos at the earliest stages of development tell their genes: "Forget what it was like in the sperm or egg where you came from."
When the process of epigenetic reprogramm...
Development and Application of a Mass Spectrometry-Based Quantitative Assay for Apolipoprotein M in Human and Mouse Serum
Mass Spectrometry Cholesterol Apolipoprotein M MS-Based Assay
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2015/5/26
Apolipoprotein M (apoM) is necessary for the formation of lipid-poor preβ-HDL particles, the initial precursor of HDL and acceptors of cholesterol efflux from peripheral cells. An assay to quantify ap...
Characterization of Bovine NANOG5′-flanking Region during Differentiation of Mouse Embryonic Stem Cells
Bovine Embryonic Stem Cell NANOG Promoter Neural Differentiation Adipocyte Differentiation
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2016/5/19
Embryonic stem cells (ESCs) have been used as a powerful tool for research including gene manipulated animal models and the study of developmental gene regulation. Among the critical regulatory factor...
Examination of Sexually Dimorphic Cell Death in the Pubertal Mouse Brain
Sexually Dimorphic Cell Death Pubertal Mouse Brain
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2014/12/12
A period of cell death during a critical period early in life is responsible for causing permanent structural changes to many brain areas, but it is not known whether cell death plays a role in brain ...
Sex Difference in Calbindin Cell Number in the Mouse Preoptic Area: Effects of Neonatal Estradiol and Bax Gene Deletion
Sex Difference Calbindin Cell Number Mouse Preoptic Area Neonatal Estradiol Bax Gene Deletion
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2014/12/12
The sexually dimorphic nucleus of the preoptic area (SDN-POA) was first discovered in rats and is one of the most famous and best studied sex differences in the field of neuroscience. Though well docu...
Using the mouse egg as a model system for the study of intracellular calcium signaling mechanisms
Oscillation eggs fertilization cell model system inositol
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2014/12/11
Mouse metaphase II (MII)-stage eggs exhibit oscillatory Ca2+ responses ([Ca2+]i oscillations) following fertilization. The wealth of information regarding Ca2+ signaling pathways in eggs has allowed t...
Estrogen and progesterone regulate p53 activity in the mouse mammary epithelium through transforming growth factor beta dependent pathways
P53 protein and tumor formation mammary gland p53 fertility estrogen and progesterone p53 radiation cells DNA damage
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2014/12/11
Proper regulation of the p53 protein plays a critical role in suppressing tumor formation in a variety of tissues including the mammary gland. Activity of the p53 pathway is diminished in the mammary ...
Regulation of p53 by Mdm4 and ovarian hormones in mouse mammary glands
P53 protein genome cell cycle DNA cell apoptosis cell growth breast cancer
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2014/12/11
p53 protein is considered a major player in maintaining the genomic integrity. It regulates cell cycle, recognizes damaged DNA, and promotes apoptosis of cells that are defective or developmentally pr...
The role of inositol 1,4,5 -trisphosphate receptor type-1 in regulation of intracellular calcium oscillations in mouse eggs
Calcium mammals fertilization eggs activation embryonic development cell cycle inositol receptor
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2014/12/11
Calcium ([Ca2+]i) oscillations, a hallmark of mammalian fertilization, are essential to induce egg activation and embryonic development. As the zygotes transition through the cell cycle, these [Ca 2+]...
From Mouse Mammary Tumor Model to New Therapeutic Method ---Mammary Tumor Development in Balb/c-Trp53+/- Mice and Magnetic Nanoparticle Induced Heating for Cancer Treatment
Breast cancer Magnetic nanoparticle Mammary gland Mouse tumor model Stem cell Thermotherapy
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2014/12/10
PATHWAYS CONTRIBUTING TO DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS IN BALB/c-Trp53+/- MICE Mutation and loss of p53 function are common features among human breast cancers. We use BALB/c-Trp53+/- mice...
CHARACTERIZATION OF Ca2+ INFLUX PATHWAY(S) DURING MOUSE OOCYTE MATURATION
Calcium influx oocyte maturation SOCE Stim1 Phosphorylation
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2014/12/10
Ca2+ signaling induced at fertilization, also known as oscillations, is essential in mammalian eggs to initiate early embryonic development. The generation of the oscillations relies on optimization o...
THE ESTRADIOL-INDUCED TRANSCRIPTOME OF THE FEMALE MOUSE ANTEROVENTRAL PERIVENTRICULAR NUCLEUS: MORE THAN JUST A KISS
Estrogen AVPV Ets2 Pdcd4 Kiss1 Ovulation
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2014/12/10
Estradiol (E2) is critical in the reproductive mechanisms of mammals. In female rodents E2 acts through the neurons of the anteroventral periventricular nucleus (AVPV) to exert neuroendocrine control ...